Шифр: ЕУ12/2006/28/2 Журнал 2006р. Т. 28 № 2 Georgolios, A. The role of CD44 adhesion molecule in oral cavity cancer / A. Georgolios [и др.] . - С.94-98 Інші автори: Batistatou A., Charalabopoulos A., Manolopoulos L., Charalabopoulos K. McShane, L. M. Reporting recommendations for tumor marker prognostic studies (remark) / L. M. McShane [и др.] . - С.99-105 Інші автори: Altman D.G., Sauerbrei W., Taube S.E., Gion M., Clark G.M. Xu, G. Antitumor activities of the four sesquiterpene lactones from ELEPHANTOPUS SCABER L / G. Xu [и др.] . - С.106-109 Інші автори: Liang Q., Gong Z., Yu W., He S., Xi I. Kyyamova, R. G. Expression of SSX2 tumor antigen in baculovirus expression system and its application for screening of blood serum of melanoma patients / R. G. Kyyamova [и др.] . - С.110-113 Інші автори: Gryshkova V.S., Zhyvoioup A.M., Korovin S.I., Gout I.T., Filonenko V.V. Olishevsky, S. Modulation of ros/no production by murine peritoneal macrophages in responseto bacterial CPG DNA stimulation / S. Olishevsky [и др.] . - С.114-120 Інші автори: Burlaka A., Sidorik E., Shiyakhovenko V., Garpenko Yu., Kozak V. Karkabounas, S. Anticarcinogenic and antiplatelet effects of carvacrol / S. Karkabounas [и др.] . - С.121-125 Інші автори: Kostoula O.K., Daskalou T., Veltsistas P., Karamouzis M., Zelovitis I., Metsios A. Hao, S. Epigenetic transfer of metastatic activity by uptake of highly metastatic B 16 melanoma cell-released exosomes / S. Hao [и др.] . - С.126-131 Інші автори: Ye Z., Meng Q., Qureshi M., Yang J., Xiang J. Shlyakhovenko, V. Application of dna from mushroom pleurotus ostreatus for cancer biotherapy: a pilot study / V. Shlyakhovenko, V. Kosak, S. Olishevsky. - С.132-135 Lu, Y. Gene therapeutic treatment of pancreatic cancer based on injection of pcDNA3.1/CCK plasmid with xenogeneic homologous cholecystokinin / Y. Lu, J. -G. Bai, H. -H. Wang. - С.136-140 Arumugam, G. Effect of gallium nitrate on tamoxifen induced hypercalcemia in rats bearing mammary tumor / G. Arumugam, P. Shanthi, P. Sachdanandam. - С.141-145 Isaikina, Y. Growth kinetics and self-renewal of human mesenchymal stem cells derived from bone marrow of children with oncohematological diseases during expansion in vitro / Y. Isaikina, A. Kustanovich, A. Svirnovski. - С.146-151 Buchynska, L. G. Expression of the cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma / L. G. Buchynska, I. P. Neslna. - С.152-155 Romanowicz-Makowska, H. Analysis of RAD51 polymorphism and BRCA 1 mutations in polish women with breast cancer / H. Romanowicz-Makowska [и др.] . - С.156-159 Інші автори: Smolarz B., Zadrowy M., Kulig A. Prylutska, S. V. Effect of the visible light irradiation of fullerene-containing composites on the ros generation and the viability of tumor cells / S. V. Prylutska [и др.] . - С.160-162 Інші автори: Burlaka A.P., Matyshevska O.P., Golub A.A., Potebnya G.P., Prylutskyy Y.I., Ritter U., Scharff P. Baran, Y. Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine / Y. Baran, V. Gunduz, A. U. Ural. - С.163-165 Glushkov, A. N. Immunological images of polycyclic aromatic hydrocarbons / A. N. Glushkov [и др.] . - С.166-168 Інші автори: Kostyanko M.V., Anosava T.P., Polenok E.G., Mun S.A., Anosov M.P., Cherno S.V. Bugdayci, G. Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer / G. Bugdayci [и др.] . - С.169-171 Інші автори: Kaplan T., Sezer S., Turban T., Koca Y., Kocer D., Yildirim E. Gluzman, D. F. Structure of leukemias and lymphomas in children of Ukraine in post-chernobyl period / D. F. Gluzman [и др.] . - С.172-174 Інші автори: Sklyarenko L.M., Nadgornaya V.A., Zavelevich M.P., Poludnenko L.Yu., Ivanwskaya T.S., Koval S.V., Simonet M.-L. Є примірники у відділах: всього 1 Вільні: 1 |
Buchynska, L. G. Expression ofthe cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma [Текст] = Особенности экспрессии регуляторов клеточного цикла p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} аденокарциномах эндометрия человека / L. G. Buchynska, I. P. Neslna // Экспериментальная онкология. - 2006. - Т. 28, № 2. - С. 152-155 Рубрики: Эндометрия новообразования Дод.точки доступу: Neslna, I. P. |
Шифр: ЕУ12/2019/41/4 Журнал 2019р. Т. 41 № 4 . - 45.41, р. Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290 Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299 Інші автори: Korovin S. I., Molnair J., Orel V. B. Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303 Інші автори: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A. Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311 Інші автори: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S. Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317 Інші автори: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A. Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322 Інші автори: Silva A. L. V., Lima C. A. D., Beltrao E. I. C. Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327 Інші автори: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E. Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334 Інші автори: Burlaka A. A., Virko S. V., Ganusevich I. I. Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341 Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345 Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352 Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356 Інші автори: Maslova G., Lymanets T., Gusachenko I. Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362 Інші автори: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S. Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365 Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367 To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369 Є примірники у відділах: Прим. 1 (вільний) |
Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina // Experimental Oncology. - 2019. - Том 41, N 4. - P335-341 Анотація: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n Дод.точки доступу: Naleskina, L. A. Nesina, I. P. Вільних прим. немає |
Шифр: ЕУ12/2018/40/4 Журнал 2018р. Т. 40 № 4 Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260 Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267 Інші автори: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S. Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274 Інші автори: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V. Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281 Інші автори: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V. Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287 Інші автори: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V. Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298 Інші автори: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I. Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302 Інші автори: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M. Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308 Інші автори: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F. Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314 Інші автори: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N. Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322 Інші автори: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I. Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327 Інші автори: Karabulut S., Erturk K., Duranyildiz D. Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331 Інші автори: Zavelevich M. P., Gluzman D. F., Kravchuk I. V., Telegeev G. D. Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335 Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342 Інші автори: Zakharova L. P., Shatrova K. M., Chitaeva G. E., Vitovsky R. M. Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344 Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345 Є примірники у відділах: Прим. 1 (вільний) |
Шифр: ЕУ12/2021/43/2 Журнал 2021р. Т. 43 № 2 Vitruk, Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue / Yu. V. Vitruk [et al.]. - С.98-103 Інші автори: Semko S. L., Voylenko O. A., Pikul M. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Stakhovsky E. O., Rossylna O. V. Pyaskovskaya, O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis / O. N. Pyaskovskaya [et al.]. - С.104-110 Інші автори: Kolesnik D. L., Garmanchouk L. V., Yanish Yu. V., Solyanik G. I. Akalovich, S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression / S. Akalovich [et al.]. - С.111-117 Інші автори: Portyanko A., Pundik A., Mezheyeuski A., Doroshenko T. Bychkov, V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines / V. A. Bychkov [et al.]. - С.118-124 Інші автори: Pevzner A. M., Nebova J. A., Ermakova N. N., Ibragimova M. K., Tsyganov M. M., Lyapunova L. S., Litviakov N. V. Ayyildiz, A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells / A. Ayyildiz [et al.]. - С.125-134 Інші автори: Koc H., Turkekul K., Erdogan S. Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko. - С.135-141 Yakovlev, P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage / P. G. Yakovlev [et al.]. - С.142-148 Інші автори: Gorbach O. I., Ostapchenko L. I., Garmanchuk L. V., Skachkova O. V., Khranovska N. M., Senchylo N. V. Zoubi, M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population / M. S. Zoubi [et al.]. - С.149-154 Інші автори: Al-Eitan L. N., Rababa D. M., Al-Batayneh K., Farzand R., Quinn G. A., Tambuwala M. M., Bakshi H. A. Kornatska, A. G. A variant of TP53 gene (RS 1625895, 13494G>A) is associated with neoplasm localization in patients with uterine leiomyoma / A. G. Kornatska [et al.]. - С.155-158 Інші автори: Flaksemberg M. A., Chubei G. V., Trokhymovych O. V., Rossokha Z. I., Fishchuk L. Ye., Medvedieva N. L., Vershyhora V. O., Gorovenko N. G. Mohamed, Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review / A. A. Mohamed Yusoff [et al.]. - С.159-167 Інші автори: Abd Radzak S. M., Mohd Khair S. Z. N., Abdullah J. M. Ben, Kridis W. Therapeutic results of laryngeal preservation: a retrospective study / W. Ben Kridis [et al.]. - С.168-172 Інші автори: Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A. Pilinska, M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro / M. A. Pilinska [et al.]. - С.173-176 Інші автори: Shemetun O. V., Talan O. O., Dibska O. B., Talko V. V. De, Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor / V. De Giorgi [et al.]. - С.177-179 Інші автори: Venturi F., Portelli F., Maida P., Scarfi F., Trane L., Gori A., Silvestri F., Massi D. Liubota, R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases / R. Liubota [et al.]. - С.180-184 Інші автори: Vereshchako R., Anikusko M., Liubota I., Vakulenko G. Pasichnyk, S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model / S. M. Pasichnyk [et al.]. - С.185-188 Інші автори: Pasichnyk M. S., Lychkovsky A. E., Stakhovsky E. O., Gozhenko A. I., Shatnyi S. V., Pasichnyk M. A. Gluzman, D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects / D. F. Gluzman [et al.]. - С.189-192 Інші автори: Zavelevich M. P., Philchenkov A. A., Koval S. V., Guslitser L. N., Zinchenko V. N., Bezhenar T. O. Є примірники у відділах: (23.05.2022р. Прим. 1 - Б.ц.) (вільний) |
Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium [Text] / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko // Experimental Oncology. - 2021. - Том 43, N 2. - P135-141 MeSH-головна: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (лекарственная терапия, метаболизм, патофизиология) Анотація: The expression of the CXCL12 chemokine and its receptor CXCR4 in the stromal component of the tumor plays an important role in tumor cell migration, proliferation, inhibition of apoptosis and determination of invasive and metastatic potential of malignant neoplasms of various genesis. The significance of CXCL12 and CXCR4 expression in endometrial tumor cells for cancer progression is not fully understood. Aim: To evaluate the content of CXCL12+-fibroblasts and expression of CXCL12 and CXCR4 in endometrial cancer cells, depending on the tumor stage. Materials and Methods: Surgical material of 45 patients with endometrioid carcinoma of the endometrium (ECE) of the stages I–II and III was studied using morphological and immunohistochemical methods. Results: In ECE of stage I–II CXCR4 expression was lower (43.3 ± 4.2%) while CXCL12 expression was higher (33.6 ± 2.4%) compared with the corresponding indices in ECE of stage III (63.6 ± 3.5%, 24.5 ± 1.9%, respectively, p 0.05). In ECE of stage III, high expression of CXCR4 ( Me) and low CXCL12 ( Me) was observed in 80% of samples; these tumors invaded more than 1/2 of the myometrium. There was a positive correlation between the depth of tumor invasion in the myometrium and the presence of metastases and CXCR4 expression in tumor cells (R Me) (14.9 ± 1.3%) was detected. Conclusion: The obtained data reflect the communication of the immunosuppressive factor of the tumor microenvironment, i.e. CXCL12+-fibroblasts and CXCR4 expressing tumor cells. We suggest that the aggressiveness of ECE is determined by the combined effect of these two factors Дод.точки доступу: Movchan, O. M. Iurchenko, N. P. Вільних прим. немає |
Шифр: ЕУ12/2017/39/4 Журнал 2017р. Т. 39 № 4 . - 34.76, р. Liubich, L. D. TGF-β1 expression by glioma C6 cells in vitro / L. D. Liubich [та ін.]. - С.258-263. - Bibliogr. at the end of the art. Інші автори: Kovalevska L. M., Lisyany M. I., Semenova V. M., Malysheva T. A., Stayno L. P., Vaslovych V. V. Pyaskovskaya, O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo / O. N. Pyaskovskaya [та ін.]. - С.264-268. - Bibliogr. at the end of the art. Інші автори: Kolesnik D. L., Fedorchuk A. G., Gorbik G. V., Solyanik G. I. Herrera-Covarrubias, D. Stress during puberty facilitates precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.269-275. - Bibliogr. at the end of the art. Інші автори: Coria-Avila G. A., Hernandez M. E., Ismail N. Caballero-Hernandez, D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure / D. Caballero-Hernandez [та ін.]. - С.276-280. - Bibliogr. at the end of the art. Інші автори: Najera-Valderrabano D., Valadez-Lira A., Franco-Molina M., Gomez-Flores R., Tamez-Guerra P., Tamez-Guerra R., Rodriguez-Padilla C. Bebeshko, V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals / V. Bebeshko, I. Homolyako, V. Grynchyshyn. - С.281-285. - Bibliogr. at the end of the art. Matveeva, A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells / A. Matveeva [та ін.]. - С.286-290. - Bibliogr. at the end of the art. Інші автори: Kovalevska L., Kholodnyuk I., Ivanivskaya T., Kashuba E. Gordiienko, I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells / I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk. - С.291-298. - Bibliogr. at the end of the art. Buchynska, L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay / L. G. Buchynska [та ін.]. - С.299-303. - Bibliogr. at the end of the art. Інші автори: Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V. Dumanskiy, Y. V. Adsorption-rheological properties of blood serum in lung cancer patients / Y. V. Dumanskiy [та ін.]. - С.304-307. - Bibliogr. at the end of the art. Інші автори: Stoliarova O. Y., Syniachenko O. V., Giulmamedova M. F., Potapov Y. A. Skrypnyk, I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia / I. Skrypnyk [та ін.]. - С.308-311. - Bibliogr. at the end of the art. Інші автори: Maslova G., Lymanets T., Gusachenko I. Buchynska, L. G. Phenotypic features of endometrial tumors in patients with family history of cancer / L. G. Buchynska [та ін.]. - С.312-318. - Bibliogr. at the end of the art. Інші автори: Lurchenko N. P., Glushchenko N. M., Nesina I. P. Patial, T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor / T. Patial [та ін.]. - С.319-321. - Bibliogr. at the end of the art. Інші автори: Sharma K., Thakur D., Gupta G. Volodymyr Serhiiovych Mosiienko (1934–2017). - С.322 Є примірники у відділах: всього 1 Вільні: 1 |
DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303. - Bibliogr. at the end of the art. Анотація: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer Дод.точки доступу: Buchynska, L. G. Brieieva, O. V. Lurchenko, N. P. Protsenko, V. V. Nespryadko, S. V. Вільних прим. немає |
Phenotypic features of endometrial tumors in patients with family history of cancer [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318. - Bibliogr. at the end of the art. Анотація: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease Дод.точки доступу: Buchynska, L. G. Lurchenko, N. P. Glushchenko, N. M. Nesina, I. P. Вільних прим. немає |
Шифр: ЕУ12/2018/40/1 Журнал 2018р. Т. 40 № 1 Kian, R. Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian. - С.2-9. - Bibliogr. at the end of the art. Patel, K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India / K. R. Patel [та ін.]. - С.10-18. - Bibliogr. at the end of the art. Інші автори: Vajaria B. N., Singh R. D., Begum R., Patel P. S. Varela-Castillo, O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach / O. Varela-Castillo [та ін.]. - С.19-23. - Bibliogr. at the end of the art. Інші автори: Cordero P., Gutierrez-Iglesias G., Palma I., Rubio-Gayosso I., Meaney E., Ramirez-Sanchez I., Villarreal F., Ceballos G., Najera N. Chaves, K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma / K. C. B. Chaves [та ін.]. - С.24-32. - Bibliogr. at the end of the art. Інші автори: Costa E. M., Teixeira L. F., Bellini M. H. Sarnatskaya, V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice / V. V. Sarnatskaya [та ін.]. - С.33-41. - Bibliogr. at the end of the art. Інші автори: Sakhno L. A., Paziuk L. M., Yushko L. A., Rodionova N. K., Maslenny V. N., Sydorenko A. S., Nikolaev V.G. Boroday, N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells / N. V. Boroday, V. F. Chekhun. - С.42-47. - Bibliogr. at the end of the art. Kurtenkov, O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients / O. Kurtenkov, M. Bubina, K. Klaamas. - С.48-58. - Bibliogr. at the end of the art. Paliychuk, O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer / O. V. Paliychuk [та ін.]. - С.59-67. - Bibliogr. at the end of the art. Інші автори: Polishchuk L. Z., Rossokha Z. I., Chekhun V. F. Buchynska, L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients / L. G. Buchynska, O. V. Brieieva. - С.68-72. - Bibliogr. at the end of the art. Lozynska, L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment / L. Y. Lozynska [та ін.]. - С.73-78. - Bibliogr. at the end of the art. Інші автори: Plawski A., Lozynska M. R., Vytvytskyi I., Lozynskyi R. Y., Prokopchuk N., Tretiak B. Zubenko, O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines / O. S. Zubenko [та ін.]. - С.79-81. - Bibliogr. at the end of the art. Інші автори: Semeniuk D. O., Starenka I. O., Pogribnyy P. V. Imaniar, R. Mediastinal yolk sac tumor infiltrating the heart / R. Imaniar [та ін.]. - С.82-84. - Bibliogr. at the end of the art. Інші автори: Syahruddin E., Soepandi P. Z., Putra A. C., Nurwidya F. Ben, Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor / Kridis W. Ben [та ін.]. - С.85-87. - Bibliogr. at the end of the art. Інші автори: Sghaier S., Toumi N., Boudawara Z., Khanfir A., Daoud J., Frikha M. Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018. - С.88 Є примірники у відділах: всього 1 Вільні: 1 |
Buchynska, L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients [Текст] / L. G. Buchynska, O. V. Brieieva // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72. - Bibliogr. at the end of the art. MeSH-головна: НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT (диагностика, патофизиология, этиология) КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (патофизиология, этиология) ЛИМФОЦИТЫ -- LYMPHOCYTES (цитология) ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (статистика, тенденции) СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL Анотація: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer Дод.точки доступу: Brieieva, O. V. Вільних прим. немає |
Шифр: ЕУ12/2018/40/3 Журнал 2018р. Т. 40 № 3 Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art. Інші автори: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S. Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art. Інші автори: Lukianova N. Y., Borikun T. V., Chekhun V. F. Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art. Інші автори: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B. Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art. Інші автори: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B. Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art. Інші автори: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu. Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art. Інші автори: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I. Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art. Інші автори: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V. Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art. Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art. Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art. Інші автори: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M. Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art. Інші автори: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H. Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art. Інші автори: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu. Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art. Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art. Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253 Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255 Yurii Yosypovych Kudryavets (1946–2018). - С.256-257 Є примірники у відділах: всього 1 Вільні: 1 |
Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma [Текст] / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 218-222. - Bibliogr. at the end of the art. Анотація: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p 0.001 and 54.5 ± 2.6%, respectively, p 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin Дод.точки доступу: Iurchenko, N. P. Buchynska, L. G. Вільних прим. немає |
Шифр: ЕУ12/2019/41/2 Журнал 2019р. Т. 41 № 2 . - 45.41, р. Verma, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies / S. Verma [та ін.]. - С.90-94. - Bibliogr. at the end of the art. Інші автори: Khambhala P., Joshi S., Kothari V., Patel T., Seshadri S. Syvyk, A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways / A. E. Syvyk, T. L. Syvyk. - С.95-105. - Bibliogr. at the end of the art. Prylutska, S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma / S. V. Prylutska [та ін.]. - С.106-111. - Bibliogr. at the end of the art. Інші автори: Lynchak O. V., Kostjukov V. V., Evstigneev M. P., Remeniak O. V., Rybalchenko V. K., Prylutskyy Yu. I., Ritter U., Scharff P. Petrellis, M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma / M. C. Petrellis [та ін.]. - С.112-122. - Bibliogr. at the end of the art. Інші автори: Frigo L., Ribeiro W., Leal-Junior E. C. P., Oliveira F. R., Maria D. A., Lopes-Martins R. Á. B. Kolesnik, D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6 / D. L. Kolesnik [та ін.]. - С.123-129. - Bibliogr. at the end of the art. Інші автори: Pyaskovskaya O. N., Yurchenko O. V., Solyanik G. I. Herrera-Covarrubias, D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.130-137. - Bibliogr. at the end of the art. Інші автори: Coria-Avila G. A., Aranda-Abreu G. E., Manzo J., Hernández M. E. Buchynska, L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko. - С.138-143. - Bibliogr. at the end of the art. Kravets, O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma / O. V. Kravets [та ін.]. - С.144-147. - Bibliogr. at the end of the art. Інші автори: Protsyk V. S., Burtyn O. V., Hlynin O. V., Hurianov V. H. Burlaka, A. P. Tumor-associated redox state in metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.148-152. - Bibliogr. at the end of the art. Інші автори: Ganusevich I. I., Burlaka A. A., Virko S. V., Kolesnik О. О. Tajaldeen, A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi / A. Tajaldeen, S. Alghamdi. - С.153-159. - Bibliogr. at the end of the art. Yakovlev, P. G. Bladder sparing surgery in high-grade bladder cancer / P. G. Yakovlev, D. A. Klyushin, R. I. Vereshchako. - С.160-165. - Bibliogr. at the end of the art. Cešeiko, R. The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment / R. Cešeiko [та ін.]. - С.166-172. - Bibliogr. at the end of the art. Інші автори: Eglītis J., Srebnijs A., Timofejevs M., Purmalis E., Erts R., Vētra A., Tomsone S. Ben, Kridis W. Prognostic factors in metastatic gastric carcinoma / Kridis W. Ben [та ін.]. - С.173-175. - Bibliogr. at the end of the art. Інші автори: Marrekchi G., Mzali R., Daoud J., Khanfir A. Dumanskiy, Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer / Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk. - С.176-178. - Bibliogr. at the end of the art. Starchenko, I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.]. - С.179-181. - Bibliogr. at the end of the art. Інші автори: Dyachenko L. V., Prylutskyi O. K., Vynnyk N. I., Filenko B. M. Ben, Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity / Kridis W. Ben [та ін.]. - С.182-184. - Bibliogr. at the end of the art. Інші автори: Werda I., Charfi S., Toumi N., Boudawara T., Mzali R., Daoud J., Khanfir A. Є примірники у відділах: всього 1 Вільні: 1 |
Buchynska, L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas [Текст] / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko // Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 138-143. - Bibliogr. at the end of the art. Анотація: To analyze copy number variations of HER-2/neu, c-MYC and CCNE1 oncogenes and their protein expression in endometrioid endometrial carcinomas in relation to the degree of tumor progression and presence of a family history of cancer in cancer patients. Materials and Methods: The study was conducted on endometrial cancer (EC) samples from 68 patients with I–II FIGO stages of disease. Copy number analysis of HER-2/neu, c-MYC and CCNE1 genes was performed by quantitative PCR. Protein expression was analyzed using immunohistochemistry. Results: Assessment of copy number variations of HER-2/neu, c-MYC and CCNE1 genes revealed their amplification in the tumors of 18.8, 25.0 and 14.3% of EC patients, respectively. High expression of corresponding proteins was detected in 14.6, 23.5 and 65.6% of patients, respectively. It was established that HER-2/neu gene amplification is more common in the group of tumors of low differentiation grade than in moderate grade EC (35.7 and 5.5% of cases, respectively, p 0.05). Also, high expression of c-Myc protein was more frequently observed in low differentiated tumors compared to the moderately differentiated EC (36.6 and 13.2% of cases, respectively, p 0.05). Expression of HER-2/neu and cyclin E proteins was found to be dependent on the depth of tumor invasion into the myometrium. High expression of HER-2/neu protein was observed in 25.0 and 4.1% of EC patients with tumor invasion ½ and ½ of the myometrium, respectively, and cyclin E — in 86.7 and 46.6% of cases, respectively, p 0.05. It was shown that among patients with a family history of cancer, a larger proportion of cases with high expression of c-Myc protein was observed compared to the group of patients with sporadic tumors (43.8 and 17.3%, respectively; p 0.05). Conclusions: Amplification of HER-2/neu gene, along with high expression of c-Myc, HER-2/neu and cyclin E proteins, are associated with such indices of tumor progression as a low differentiation grade and deep myometrial invasion, suggesting the potential possibility of including these markers in the panel for determining the molecular EC subtype associated with an aggressive course of the disease. In a certain category of EC patients, there is a relationship between a family history of cancer and high expression of c-Myc protein Дод.точки доступу: Brieiev, O. V. Iurchenko, N. P. Вільних прим. немає |