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Шифр: УУ60/2018/90/1 Журнал 2018р. Т. 90 № 1 Danylovych, G. V. The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria / G. V. Danylovych, T. V. Bohach, Yu. V. Danylovych. - P.3-24 Danylovych, G. V. Calix[4]arene C-956 is effective inhibitor of H+-Ca2+-exchanger in smooth muscle mitochondria / G. V. Danylovych [et al.]. - P.25-33 Інші автори: Kolomiets O. V., Danylovych Yu. V., Rodik R. V., Kalchenko V. I., Kosterin S. O. Shahouzehi, B. Effects of Pistacia atlantica resin oil on the level of VEGF, hydroxyproline, antioxidant and wound healing activity in STZ-induced diabetic rats / B. Shahouzehi [et al.]. - P.34-41 Інші автори: Shabani M., Shahrokhi N., Sadeghiyan S., Masoumi-Ardakani Y. Voloshchuk, O. M. Activity of the mitochondrial isoenzymes of endogenous aldehydes catabolism under the conditions of acetaminophen-induced hepatitis / O. M. Voloshchuk, G. P. Kopylchuk, Y. I. Mishyna. - P.42-47 Fafula, R. V. Responsiveness to progesterone and potassium channel blockers 4-aminopyridine, tetraethylammonium and free Ca2+ contentration in spermatozoa of patients with oligozoospermia/leucocytospermia / R. V. Fafula [et al.]. - P.48-57 Інші автори: Danylovych G. V., Besedina A. S., Melnyk O. V., Vorobets Z. D. Yusova, O. I. Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension / O. I. Yusova [et al.]. - P.58-67 Інші автори: Savchuk O. V., Grinenko T. V., Kuchmenko O. B., Mhitaryan L. S., Kupchins’ka O. H., Yevstratova I. N., Matova O. O., Vasilinchuk N. M., Drobot’ko T. F. Salmanian, Tabasi N. Designing, docking and heterologous expression of an anti-her2 affibody molecule / N. Salmanian Tabasi, A. Gholizadeh, B. Baghban Kohnehrouz. - P.68-76 Луговська, Г. Г. Інноваційна діяльність інституту біохімії ім. О. В. Палладіна НАН України: проблеми і перспективи / Г. Г. Луговська, В. М. Данилова, С. В. Комісаренко. - P.77-99 Є примірники у відділах: Прим. 1 (вільний) |
Danylovych, G. V. The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria / G. V. Danylovych, T. V. Bohach, Yu. V. Danylovych // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 1. - P3-24 MeSH-головна: АЗОТА ОКСИДЫ -- NITROGEN OXIDES (химия) МИТОХОНДРИИ МЫШЦ -- MITOCHONDRIA, MUSCLE (ультраструктура, физиология) КЛЕТОЧНАЯ КОМПАРТМЕНТАЦИЯ -- CELL COMPARTMENTATION ЭУКАРИОТЫ -- EUKARYOTA Анотація: Modern data on biochemical patterns of nitric oxide biosynthesis in mammal cells from L-arginine in normoxic conditions is described. The attention of the authors is given to the results of the recent years on the structure and regulation features isoforms of NO-synthase. The emphasis is put on the latest conception of the compartmentalization of certain isoforms of these enzymes in cells and on the possibility of the directed transport of nitric oxide in the vascular wall. The central place in the review is devoted to issues on the endogenous formation of NO in mitochondria and its potential physiological significance. Our own results on the identification of NO in mitochondria of the uterine smooth muscle, biochemical characteristics of this process and NO possible role in Са2+ transport regulation by organelles are presented and discussed Дод.точки доступу: Bohach, T. V. Danylovych, Yu. V. Вільних прим. немає |
Calix[4]arene C-956 is effective inhibitor of H+-Ca2+-exchanger in smooth muscle mitochondria / G. V. Danylovych [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 1. - P25-33 MeSH-головна: КАЛИКСАРЕНЫ -- CALIXARENES (химия) МИТОХОНДРИИ МЫШЦ -- MITOCHONDRIA, MUSCLE (ультраструктура, физиология) ЭУКАРИОТЫ -- EUKARYOTA Анотація: It was shown that calix[4]arene C-956 exhibited a pronounced concentration-dependent (10-100 μM) inhibitory effect on the H+-Ca2+-exchanger of the inner mitochondrial membrane of rat uterine myocytes (Ki 35.1 ± 7.9 μM). The inhibitory effect of calix[4]arene C-956 was accompanied by a decrease in the initial rate (V0) and an increase in the magnitude of the characteristic time (τ1/2) of the ΔрН-induced Са2+ release. At the same time, it did not affect the potential-dependent accumulation of Ca2+ in mitochondria. Thus, the action of calix[4]arene C-956 might be directed on increasing the concentration of Ca ions in the mitochondrial matrix. The calculation of basic kinetic parameters of the Ca2+ transport from isolated organelles (in the case of its non-zero stationary level), based on changes in fluorescence of Ca2+-sensitive dye Fluo-4 AM in mitochondria was performed. The proposed approach can be used for the kinetic analysis of the exponential decrease of the fluorescence response of any probes under the same experimental conditions Дод.точки доступу: Danylovych, G. V. Kolomiets, O. V. Danylovych, Yu. V. Rodik, R. V. Kalchenko, V. I. Kosterin, S. O. Вільних прим. немає |
Responsiveness to progesterone and potassium channel blockers 4-aminopyridine, tetraethylammonium and free Ca2+ contentration in spermatozoa of patients with oligozoospermia/leucocytospermia / R. V. Fafula [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 1. - P48-57 MeSH-головна: КАЛЬЦИЙ -- CALCIUM СПЕРМАТОЗОИДЫ -- SPERMATOZOA ПРОГЕСТЕРОН -- PROGESTERONE КАЛЬЦИЕВЫХ КАНАЛОВ БЛОКАТОРЫ -- CALCIUM CHANNEL BLOCKERS ОЛИГОСПЕРМИЯ -- OLIGOSPERMIA ЭУКАРИОТЫ -- EUKARYOTA Анотація: The present study was undertaken to evaluate [Ca2+]i signals that occur in human sperm cells exposed in vitro to three diverse compounds; progesterone, 4-aminopyridine (a highly effective inducer of hyperactivation in human sperm) and tetraethylammonium. The [Ca2+]i reached after the extracellular calcium treatment was always higher in normozoospermic samples pretreated with progesterone than in pathozoospermic samples pretreated with progesterone. There were no changes in calcium signal in spermatozoa pretreated with progesterone from patients with oligozoospermia and leucocytospermia compared to control samples (without progesterone). [Ca2+]i was always higher in pathozoospermic samples without 4-aminopyridine and always lower in pathozoospermic samples with 4-aminopyridine compared to these values in normozoospermic men. The 2 mM extracellular calcium administration to spermatozoa pretreated with tetraethylammonium did not result in a detectable increase in [Ca2+]i in normo- and pathozoospermic samples. The mechanisms of progesterone-dependent activation of the Ca2+-entry and the functioning of the voltage gated Ca2+-channels of plasmalemma are disturbed in pathologies – there was no increase in the Ca2+ level in the conditions of K+-depolarization (in the presence of inhibitors of K+-channels) Дод.точки доступу: Fafula, R. V. Danylovych, G. V. Besedina, A. S. Melnyk, O. V. Vorobets, Z. D. Вільних прим. немає |