> Шифр: МУ96/2017/3/1 Журнал 2017р. т.3 N 1 Venger, O. P. Improvement in the approaches to the treatment of emigrants and re-emigrants with depressive disorders / O. P. Venger, Y. I. Mysula, L. V. Shkrobot. - С.5-10 Kedyk, A. V. Screening for dyslipidemia and expedience of statin therapy for the citizens of transcarpathia valley regions with overweight and obesity / A. V. Kedyk, M. V. Rishko, O. O. Kutsyn. - С.11-14 Oleshchuk, O. M. Leptin resistance and type 2 diabetes / O. M. Oleshchuk, H. Ya. Loi. - С.15-21 Martynyuk, L. Z. The effect of L-arginine on oxidative stress and microalbuminuria in patients with type 2 diabetes mellitus and chronic kidney disease / L. Z. Martynyuk, L. Z. Vons, O. O. Ruzhytska. - С.22-25 Sarapuk, I. M. Neurodevelopmental care of preterm infants and its key / I. M. Sarapuk [и др.]. - С.26-33 Інші автори: Pavlyshyn H. A., Lacina L., Krolak-Olejnik B. Vergun, A. R. Chronic mycotic-associated surgical nail pathology complicated with ingrown nail (nail incarnation): the analyses of clinical cases and complex treatment / A. R. Vergun [и др.]. - С.34-40 Інші автори: Parashchuk B. M., Krasnyi M. R., Kit Z. M., Vergun O. M. Hasiuk, N. V. Pathogenic mechanisms of generalized periodontitis from the position of polymorphism of nuclear transcription / N. V. Hasiuk [и др.]. - С.41-46 Інші автори: Vesnina L. E., Shlykova O. A., Izmailova O. V. Kostenko, Ye. Ya. The effectivness of chronic gingivites treatment in patients with non-removable orthodontic apparatus according to the results of periodontal tissues index assessment / Ye. Ya. Kostenko, V. S. Melnyk, L. F. Horzov. - С.47-49 Kalinichenko, S. V. Influence of lactobacillus spp. on colonization and anti-infectious resistance of the mucous membranes of the upper respiratory tract / S. V. Kalinichenko [и др.]. - С.50-59 Інші автори: Korotkykh O. O., Pokhil S. I., Bakumenko M. G. Melnyk, L. P. Awareness of lyme borreliosis of the patients of ternopil regional tb dispensary / L. P. Melnyk [и др.]. - С.60-63 Інші автори: Hryshchuk L. A., Koziol-Montewka M., Tabas P. O., Klos R. O. Nazarchuk, O. A. Research in sensitivity to antibiotics, antiseptics in pseudomonas aeruginosa strains isolated from patients with infectious complications / O. A. Nazarchuk, D. V. Paliy, N. I. Osadchuk. - С.64-69 Boiagina, O. D. Morphological study of communication between the longitudinal strips and the human corpus callosum / O. D. Boiagina. - С.70-74 Ilika, V. V. Morphological research on free-residue oxidation processes in cases of decidual cells of placenta in chorioamnionotis and basal deciduitis combined with iron-deficiency anemia in the pregnant / V. V. Ilika. - С.75-78 Khudobiak, M. M. Morphological changes in lungs, heart and liver caused by experimental associated chest and thighs trauma / M. M. Khudobiak, M. I. Marushchak, L. M. Holovatiuk. - С.79-83 Lykhatskyi, P. H. Free radicals and inflammation in rats of different age in cases of sodium nitrites and tobacco smoke poisoning / P. H. Lykhatskyi, L. S. Fira. - С.84-88 Є примірники у відділах: всього 1 Вільні: 1 |
Oleshchuk, O. M. Leptin resistance and type 2 diabetes [Text] / O. M. Oleshchuk, H. Ya. Loi> // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P15-21 MeSH-головна: ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2 ЛЕПТИН -- LEPTIN Анотація: Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat. Leptin concentration increases when surfeit and decreases during fasting. Obese patients are hyperleptinemic compared with thin persons and they are tolerant to the central hypothalamic effects of leptin. The reduced sensitivity toward exogenous and endogenous leptin is commonly referred to as leptin resistance. Alterations in the signaling of the long isoform of the leptin receptor play the crucial role in leptin resistance. Surfeit may induce leptin resistance and other metabolic sequelae of obesity. Leptin insensitivity and insulin resistance play a major role in the development of type 2 diabetes. Metformin remains the preferred first-line pharmacologic agent for the treatment of type 2 diabetes. It reduces hepatic glucose production, increases glucose uptake in peripheral tissue and can lead to weight loss. Metformin decreases both insulin and leptin concentration, restores the sensitivity to these hormones. But some studies have shown poor relationship between metformin action and leptin level. And the mechanism of metformin action on leptin resistance remains unclear. Thus, these issues should be studied as well as polymorphisms in genes encoding metformin action Дод.точки доступу: Loi, H. Ya. Вільних прим. немає |