Шифр: УУ1/2016/88/1 Журнал 2016г. Т. 88 № 1 Uspenska, K. R. The effect of amixin and agmatine on cytochrome c release from isolated mitochondria / K. R. Uspenska [и др.]. - С.5-10. - Бібліогр.: в кінці ст. Другие авторы: Gergalova G. L., Lykhmus O. Yu., Skok M. V. Minchenko, O. H. Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of IRE1 signaling enzyme / O. H. Minchenko [и др.]. - С.11-21. - Бібліогр.: в кінці ст. Другие авторы: Tsymbal D. O., Minchenko D. O., Riabovol O. O., Ratushna O. O., Karbovskyi L. L. Sandeep, S. Multiple parametric approaches to assess acute radiation lung injury of rats / S. Sandeep [и др.]. - С.22-30. - Бібліогр.: в кінці ст. Другие авторы: Mitra B., Priyanka A., Neeraj K., Aseem B., Neelam C. Danylovych, H. V. Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence / H. V. Danylovych. - С.31-43. - Бібліогр.: в кінці ст. Franskevych, D. V. Modulation of cisplatin-induced reactive oxygen species production by fullerene C(60) in normal and transformed lymphoid cells / D. V. Franskevych [и др.]. - С.44-50. - Бібліогр.: в кінці ст. Другие авторы: Grynyuk I. I., Prylutska S. V., Matyshevska O. P. Kоbylinska, L. I. Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier / L. I. Kоbylinska [и др.]. - С.51-60. - Бібліогр.: в кінці ст. Другие авторы: Havrylyuk D. Ya., Mitina N. E., Zаichenko A. S., Lesyk R. B., Zіmenkovsky B. S., Stoika R. S. Rakhmetov, A. D. Prx II and CKBB proteins interaction under physiological and thermal stress conditions in A549 and HeLa cells / A. D. Rakhmetov [и др.]. - С.61-68. - Бібліогр.: в кінці ст. Другие авторы: Lee Sang Pil, Ostapchenko L. I., Chae Ho Zoon Olkhovych, N. V. Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases / N. V. Olkhovych. - С.69-78. - Бібліогр.: в кінці ст. Gudkova, O. O. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats / O. O. Gudkova, N. V. Latyshko, S. G. Shandrenko. - С.79-87. - Бібліогр.: в кінці ст. Korneeva, K. L. Expression of genes, encoding the enzymes of cysteine metabolism in human placenta in the first and third trimesters of uncomplicated pregnancy / K. L. Korneeva [и др.]. - С.88-98. - Бібліогр.: в кінці ст. Другие авторы: Rodriguez R. R., Ralchenko S. V., Martunovska O. V., Frolova A. О., Martsenyuk O. P., Manzhula L. V., Melnyk V. T., Shkoropad O. Y., Obolenska M. Yu. Chekhun, V. F. Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents / V. F. Chekhun [и др.]. - С.99-108. - Бібліогр.: в кінці ст. Другие авторы: Lozovska Yu. V., Burlaka A. P., Ganusevich I. I., Shvets Yu. V., Lukyanova N. Yu., Todor I. M., Tregubova N. A., Naleskina L. A. Sokolik, V. V. Effect of β-amyloid peptide 42 on the dynamics of expression and formation of Аβ(40), IL-1β, TNFα, IL-6, IL-10 by peripheral blood mononuclear cells in vitro and its correction by curcumin / V. V. Sokolik, O. K. Koliada, S. M. Shulga. - С.109-118. - Бібліогр.: в кінці ст. Bazalii, A. V. Transcriptional regulation of NOX genes expression in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN85 / A. V. Bazalii [и др.]. - С.119-125. - Бібліогр.: в кінці ст. Другие авторы: Horak I. R., Pasichnyk G. V., Komisarenko S. V., Drobot L. B. Данилова, В. М. Аналіз винахідницької діяльності відділу біохімії вітамінів і коензимів Інституту біохімії ім. О. В. Палладіна НАН України в 1980–2015 рр. / В. М. Данилова [и др.]. - С.126-140. - Бібліогр.: в кінці ст. Другие авторы: Черниш І. Г., Виноградова Р. П., Луговська Г. Г., Юрасова С. П. Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Шифр: ЕУ12/2017/39/1 Журнал 2017г. Т. 39 № 1 Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il. Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил. Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил. Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл. Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il. Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il. Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл. EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл. Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл. Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл. Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл. Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл. The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл. Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил. Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил. Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93 Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89 The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89 Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90 Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90 CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91 CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92 Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92 The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92 High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93 Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93 Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93 Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94 International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics / V. F. Chekhun [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P25-29 : табл. - 21 ref. MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия) АРТЕМИЗИНИНЫ -- ARTEMISININS ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE Аннотация: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin — Dox; cisplatin — DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. Materials and Methods: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid. The latter was added to modulate iron levels in the cells and explore its role in artemisinin-induced effects. The MTT assay was used to monitor cell viability, whereas changes of expression of selected proteins participating in regulation of cellular iron homeostasis were estimated using immunocytochemical methods. Finally, relative expression levels of miRNA-200b, -320a, and -34a were examined by using qRT-PCR. Results: Artemisinin affects mechanisms of the resistance of breast cancer cells towards both Dox and DDP at sub-toxic doses. The former drug induces changes of expression of iron-regulating proteins via different mechanisms, including epigenetic regulation. Particularly, the disturbances in ferritin heavy chain 1, lactoferrin, hepcidin (decrease) and ferroportin (increase) expression (р ≤ 0.05) were established. The most enhanced increase of miRNA expression under artemisinin influence were found for miRNA-200b in MCF-7/DDP cells (7.1 ± 0.98 fold change), miRNA-320a in MCF-7/Dox cells (2.9 ± 0.45 fold change) and miRNA-34a (1.7 ± 0.15 fold change) in MCF-7/S cells. It was observed that the sensitivity to artemisinin can be influenced by changing iron levels in cells. Conclusions: Artemisinin can modify iron metabolism of breast cancer cells by its cytotoxic effect, but also by inducing changes in expression of iron-regulating proteins and microRNAs (miRNAs), involved in their regulation. This modification affects the mechanisms that are implicated in drug-resistance, that makes artemisinin a perspective modulator of cell sensitivity towards chemotherapeutic agents in cancer treatment Доп.точки доступа: Chekhun, V.F. Lukianova, N.Y. Borikun, T.V. Zadvornyi, T.V. Mokhir, A. Свободных экз. нет |
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova // Experimental Oncology. - 2017. - Том 39, N 1. - P65-68 : табл. - 16 ref. MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия) ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT СИМПОРТЕРЫ -- SYMPORTERS Аннотация: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients Доп.точки доступа: Andriiv, A.V. Lukianova, N.Yu. Свободных экз. нет |
Шифр: УУ60/2017/89/2 Журнал 2017г. Т. 89 № 2 Shtemenko, A. V. Rhenium-platinum antitumor systems / A. V. Shtemenko, N. I. Shtemenko. - P.5-30 Minchenko, O. H. Effect of chromium disilicide and titanium nitride nanoparticles on the expression of NAMPT, E2F8, FAS, TBX3, IL13RA2, and UPS7 genes in mouse liver / О. Н. Minchenko [et al.]. - P.31-42 Другие авторы: Yavorovsky O. P., Solokha N. V., Minchenko D. O., Kuznetsova A. Y. Tykhomyrov, A. A. Plasminogen and its fragments in rat brain: a plausible role for astrocytes in angiostatin generation / A. A. Tykhomyrov [et al.]. - P.43-54 Другие авторы: Nedzvetsky V. S., Agca C. A., Korsa V. V., Grinenko T. V. Minchenko, O. H. IRE1 knockdown modifies hypoxic regulation of cathepsins and LONP1 genes expression in U87 glioma cells / О. Н. Minchenko [et al.]. - P.55-69 Другие авторы: Riabovol О. O., Halkin O. V., Minchenko D. O., Ratushna O. O. Kaplia, A. A. Different sensitivity of Na+,K+-ATPase and Mg2+-ATPase to ethanol and arachidonic acid in rat colon smooth muscle under pretreatment of cellular membranes with Ds-Na / A. A. Kaplia. - P.70-77 Biliavska, L. O. Sterols biosynthesis by soil streptomycetes / L. O. Biliavska [et al.]. - P.78-84 Другие авторы: Ostapchuk A. M., Voychuk S. I., Iutynska G. O. Kosyk, O. I. Phenylalanine ammonia-lyase activity and anthocyanin content in different varieties of lettuce under the cadmium influence / O. I. Kosyk [et al.]. - P.85-91 Другие авторы: Khomenko I. M., Batsmanova L. M., Taran N. Yu. Kopylchuk, H. P. Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation / H. P. Kopylchuk, I. M. Nykolaichuk, O. M. Zhuretska. - P.92-98 Korol, L. V. Intensity of oxidative stress and activity of angiotensin converting enzyme in blood of patients with uncomplicated pyelonephritis / L. V. Korol, L. Ya. Mygal, N. M. Stepanova. - P.99-105 Kozachkova, O. M. Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.]. - P.106-115 Другие авторы: Tsaryk N. V., Trachevskyi V. V., Rozhenko A. B., Shermolovich Yu. H., Guzyr O. I., Sharykina N. I., Chekhun V. F., Pekhnyo V. I. Ellidag, H. Y. A novel method for negating cold agglutination interference by dithiothreitol during complete blood count and peripheral blood smear: a case study / H. Y. Ellidag [et al.]. - P.116-120 Другие авторы: Kulaksizoglu S., Eren E., Yilmaz N. Данилова, В. М. Науково-практична діяльність відділу нейрохімії Інституту біохімії ім. О. В. Палладіна НАН України / В. М. Данилова, Р. П. Виноградова, Г. Г. Луговська. - P.121-134 Вельмишановна та дорога Валентино Михайлівно! (до 80-річчя від дня народження). - P.135 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 2. - P106-115 MeSH-главная: ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (терапевтическое применение) ПАЛЛАДИЙ -- PALLADIUM (терапевтическое применение) Аннотация: Complex formation of K[[d]]2[[/d]][PdCl[[d]]4[[/d]]] with 1-phenyl-1-hydroxymethylene bisphosphonic acid (PhHMBP, H[[d]]4[[/d]]L) has been studied by pH potentiometry, electron and NMR spectroscopy. It was found that in aqueous solution with physiological concentration of chlorine anions (0.15 mol/l KCl), anionic complexes of the equimolar compositions [PdHLCl[[d]]2[[/d]]][[p]]3-[[/p]] (lgβ = 24.51 (0.3)) and [PdLCl[[d]]2[[/d]]][[p]]4- [[/p]](lgβ = 20.74 (0.02)) are formed. In the first coordination sphere palladium was surrounded by two oxygen atoms of two phosphonic groups of the bidentately coordinated ligand with closure of six-membered [O, O] ring, and two chlorine anions. The formation of palladium(II) equimolar complexes with PhHMBP and bidentate coordination of the ligand to the central metal cation was confirmed by[[p]] 31[[/p]]P NMR spectroscopy. Cytotoxic activity (IC[[d]]50[[/d]] based on metal content) of the synthesized Pd(II) complexes with PhHMBP against human MG-63 osteosarcoma and MCF-7 mammary tumor cells was compared with cisplatin on in vitro models. It was established that cytotoxic activity of the Pd complexes was lower than that of cisplatin. The acute toxicity (LD[[d]]50[[/d]] based on metal content) of solutions of Pd(II) complexes with PhHMBP was found to be lower compared to cisplatin. It was shown that the use of solutions of palladium(II) complexes with PhHMBP inhibited tumor growth in mice with sarcoma 180 Доп.точки доступа: Kozachkova, O. M. Tsaryk, N. V. Trachevskyi, V. V. Rozhenko, A. B. Shermolovich, Yu. H. Guzyr, O. I. Sharykina, N. I. Chekhun, V. F. Pekhnyo, V. I. |
Шифр: ЕУ12/2019/41/4 Журнал 2019г. Т. 41 № 4 . - 45.41, р. Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290 Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299 Другие авторы: Korovin S. I., Molnair J., Orel V. B. Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303 Другие авторы: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A. Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311 Другие авторы: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S. Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317 Другие авторы: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A. Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322 Другие авторы: Silva A. L. V., Lima C. A. D., Beltrao E. I. C. Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327 Другие авторы: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E. Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334 Другие авторы: Burlaka A. A., Virko S. V., Ganusevich I. I. Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341 Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345 Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352 Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356 Другие авторы: Maslova G., Lymanets T., Gusachenko I. Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362 Другие авторы: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S. Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365 Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367 To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun // Experimental Oncology. - 2019. - Том 41, N 4. - P282-290 Аннотация: The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity Доп.точки доступа: Ivanchenko, A. V. Chekhun, V. F. Свободных экз. нет |
Шифр: ЕУ12/2020/42/2 Журнал 2020г. Т. 42 № 2 Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun. - С.82-93 Zadvornyi, T. V. Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.]. - С.94-100 Другие авторы: Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F. Lamdan, H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin / H. Lamdan [et al.]. - С.101-108 Другие авторы: Garcia-Lazaro R. S., Lorenzo N., Galigiuri L. G., Alonso D. F., Farina H. G. Antonenko, S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells / S. V. Antonenko, G. D. Telegeev. - С.109-114 Onyshchenko, K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma / K. V. Onyshchenko [et al.]. - С.115-119 Другие авторы: Voitsitskyi T. V., Grygorenko V. M., Saidakova N. O., Pereta L. V., Onyschuk A. P., Skrypkina I. Ya. Stegantseva, M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model / M. V. Stegantseva [et al.]. - С.120-125 Другие авторы: Shinkevich V. A., Tumar E. M., Meleshko A. N. Andreieva, S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias / S. V. Andreieva [et al.]. - С.126-129 Другие авторы: Kyselova O. A., Serbin I. M., Alkhimova O. G. Bialik, P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer / P. Bialik [et al.]. - С.130-134 Другие авторы: Wysokinski D., Slomka M., Morawiec Z., Strapagiel D., Wozniak K. Pankaj, D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study / D. Pankaj, V. Guddattu, M. C. Solomon. - С.135-139 Lyalkin, S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer / S. A. Lyalkin [et al.]. - С.140-143 Другие авторы: Verevkina N. O., Alekseyenko O. O., Syvak L. A. Perekhrestenko, T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy / T. Perekhrestenko [et al.]. - С.144-147 Другие авторы: Melnyk U., Goryainova N., Diagil I. Glavatskyi, O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy / O. Ya. Glavatskyi [et al.]. - С.148-156 Другие авторы: Zemskova O. V., Khmelnytskyi H. V., Kardash K. A., Shuba I. M., Stuley V. A. Kliusov, O. M. Specialized care provided to patients with rectal cancer in Kyiv city / O. M. Kliusov. - С.157-160 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun // Experimental Oncology. - 2020. - Том 42, N 2. - P82-93 MeSH-главная: НОВООБРАЗОВАНИЯ -- NEOPLASMS (лекарственная терапия, микробиология) Аннотация: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity Доп.точки доступа: Lukianova, N. Yu. Chekhun, V. F. Свободных экз. нет |
Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.] // Experimental Oncology. - 2020. - Том 42, N 2. - P94-100 MeSH-главная: ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (терапия) Аннотация: The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p 0.05 and r Доп.точки доступа: Zadvornyi, T. V. Lukianova, N. Yu. Borikun, T. V. Vitruk, Yu. V. Stakhovsky, E. O. Chekhun, V. F. Свободных экз. нет |
Шифр: ЕУ12/2018/40/4 Журнал 2018г. Т. 40 № 4 Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260 Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267 Другие авторы: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S. Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274 Другие авторы: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V. Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281 Другие авторы: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V. Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287 Другие авторы: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V. Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298 Другие авторы: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I. Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302 Другие авторы: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M. Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308 Другие авторы: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F. Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314 Другие авторы: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N. Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322 Другие авторы: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I. Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327 Другие авторы: Karabulut S., Erturk K., Duranyildiz D. Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331 Другие авторы: Zavelevich M. P., Gluzman D. F., Kravchuk I. V., Telegeev G. D. Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335 Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342 Другие авторы: Zakharova L. P., Shatrova K. M., Chitaeva G. E., Vitovsky R. M. Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344 Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F. Chekhun // Experimental Oncology. - 2018. - Том 40, N 4. - P258-260 MeSH-главная: ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (организация и управление, тенденции) АКАДЕМИИ И ИНСТИТУТЫ -- ACADEMIES AND INSTITUTES (история, организация и управление, тенденции) УКРАИНА -- UKRAINE Аннотация: Fluctuation of time is determined by the order and sequence of historical events of global and/or local scale, the harmonization of which reflects the dynamics of the development of society. The top of universal values of this process was and remains the academic science, which is based on the principles of an inextricable triad: education, science and culture. The intellectual and creative “explosion” of the 20th and the beginning of the 21st century has fundamentally changed human consciousness and priority values. Along with the knowledge of physical, natural phenomena and the search for energy sources, man has become not only a subject, but also an object of research. The pace of development of the life sciences reached the apogee. The struggle for higher expectancy and quality of life is a priority of modern science. The key problem of biomedical research has been and remains malignant neoplasms, which dynamics becomes a threat of civilizational scale Доп.точки доступа: Chekhun, V. F. \ed.\ Свободных экз. нет |
Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274 MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология) Аннотация: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance Доп.точки доступа: Chekhun, V. F. Todor, I. N. Lukianova, N. Yu. Horbyk, D. M. Lozovskaya, Yu. V. Burlaka, A. P. Borikun, T. V. Свободных экз. нет |
Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P303-308 MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, метаболизм, патофизиология) ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS (метаболизм) Аннотация: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients Доп.точки доступа: Buchynska, L. G. Iurchenko, N. P. Kashuba, E. V. Brieieva, O. V. Glushchenko, N. M. Mints, M. Lukianova, N. Yu. Chekhun, V. F. Свободных экз. нет |
Шифр: ЕУ12/2021/43/3 Журнал 2021г. Т. 43 № 3 To the thirties anniversary of the independence of Ukraine priorities in cancer research: retrospective and prospective aspects. - С.194-196 Chumak, A. V. Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma / A. V. Chumak [et al.]. - С.197-203 Другие авторы: Fedosova N. I., Shcherbina V. M., Cheremshenko N. L., Karaman O. M., Chekhun V. F. Kovalevska, L. M. Expression pattern of MRPS 18 family genes in gliomas / L. M. Kovalevska [et al.]. - С.204-208 Другие авторы: Malysheva T. A., Kalman S. S., Rozumenko A. V., Verbova L. V., Rozumenko V. D., Kashuba E. V. Roomi, M. W. A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells IN VIVO and IN VITRO by inhibiting MMPS and inducing apoptosis / M. W. Roomi [et al.]. - С.209-216 Другие авторы: Bhanap B., Niedzwiecki A., Rath M. Khranovska, N. Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy / N. Khranovska [et al.]. - С.217-223 Другие авторы: Shachkova O., Gorbach O., Inomistova M., Orel V. Abramenko, I. Association of lipoprotein lipase expression with TP53 gene polymorphisms in chronic lymphocytic leukemia cells / I. Abramenko [et al.]. - С.224-228 Другие авторы: Bilous N., Chumak A., Dyagil I., Martina Z. Zotova, O. V. 11q23/MLL rearrangements in adult acute leukemia / O. V. Zotova [et al.]. - С.229-233 Другие авторы: Lukianova A. S., Valchuk M. O., Karol Yu. S., Dhalay O. O., Novak V. L., Loginsky V. E. Horacek, J. M. Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival / J. M. Horacek [et al.]. - С.234-236 Другие авторы: Kupsa T., Vanek J., Jakl M., Stajer M., Jebavy L., Zak P. Konovalenko, V. F. Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal / V. F. Konovalenko [et al.]. - С.237-241 Другие авторы: Ternovyi N. K., Tuz E. V., Protsenko V. V., Solonitsyn E. O., Udai A., Drobotun O. V., Ulianchych N. V. Ivankova, V. S. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients / V. S. Ivankova [et al.]. - С.242-246 Другие авторы: Domina E. A., Khrulenko T. V., Makovetska L. I., Hrinchenko O. O., Baranovska L. M. Rawoot, S. Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know? / S. Rawoot [et al.]. - С.247-251 Другие авторы: Punatar C., Singh V., Anand A., Shah B., Nagaonkar S., Joshi V. Vlachou, M. S. Plasma ctDNA ras status selects patients for anti-EGER treatment rechallenge in metastatic colorectal cancer: a meta-analysis / M. S. Vlachou [et al.]. - С.252-256 Другие авторы: Mauri D., Zarkavelis G., Ntellas P., Tagkas C., Gkoura S., Pentheroudakis G. Kukushkina, M. Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors / M. Kukushkina [et al.]. - С.252-260 Другие авторы: Korovin S., Diedkov S., Ostafiichuk V., Diedkov A. Burlaka, A. P. Redox dependent features of tumors, adipose tissue. neutrophiles and platelets in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.261-265 Другие авторы: Virko S. V., Burlaka A. A., Krupnyk K. L. Kornatska, A. G. ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopapthy in infertile women / A. G. Kornatska [et al.]. - С.266-269 Другие авторы: Rossokha Z. I., Fishchuk L. Ye., Dubenko O. D., Medvedieva N. I., Haksemberg M. A., Chubei G. V., Popova O. F., Gorovenko N. G. Solyanik, G. I. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma / G. I. Solyanik [et al.]. - С.270-276 Другие авторы: Karaman O. M., Yakshibaeva Y. R., Pyaskovskaya O. N., Kolesnyk D. I. Chekhun, V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background) / V. F. Chekhun, E. A. Domina. - С.277-280 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma / A. V. Chumak [et al.] // Experimental Oncology. - 2021. - Том 43, N 3. - P197-203 MeSH-главная: КАРЦИНОМА, ЭРЛИХА ОПУХОЛЬ -- CARCINOMA, EHRLICH TUMOR (лекарственная терапия) ИММУНОТЕРАПИЯ -- IMMUNOTHERAPY (использование, методы) МАКРОФАГИ -- MACROPHAGES (действие лекарственных препаратов) ЭУКАРИОТЫ -- EUKARYOTA Аннотация: Recent studies have shown the potential of using different approaches for immunotherapy in cancer treatment. Macrophages (Mph) are one of the promising targets for immunotherapy. Aim: To investigate changes in the functional activity of Mph in mice with Ehrlich carcinoma by nitric oxide (NO)/arginase (Arg), IRF4/IRF5 and STAT1/STAT6 ratios caused by administration of lectin from B. subtilis IMV-7724. Materials and Methods: From the 2nd day after Ehrlich carcinoma inoculation into female Balb/c mice, lectin from B. subtilis IMV B-7724 (0.02 mg/mouse) was administered for 10 days. The peritoneal Mph were isolated on days 14, 21, and 28 after tumor transplantation and their functional state (NO production, Arg activity and cytotoxic activity) was examined. The levels of mRNA expression of transcription factors STAT-1, STAT-6, IRF5, IRF4 were evaluated. Results: In lectin-treated animals with Ehrlich carcinoma, the functional state of Mph (NO/Arg ratio, index of cytotoxic activity) was maintained at the level of intact mice exceeding the values in untreated animals with Ehrlich carcinoma at late terms of tumor growth (21, 28 days). Analysis of mRNA expression levels of transcription factors in these animals showed a significant increase (p 0.05) in the ratio of STAT1/STAT6 on the day 21 and IRF5/IRF4 on day 28 of tumor growth compared to that in untreated mice. Conclusions: Administration of lectin from B. subtilis IMV B-7724 to mice with Ehrlich carcinoma led to the prevalence of Mph exhibiting the functional properties of M1 type at late-term tumor growth. The transcription factors of the STAT and IRF signaling pathways are involved in the process of Mph polarization induced by lectin from B. subtilis IMV B-7724 Доп.точки доступа: Chumak, A. V. Fedosova, N. I. Shcherbina, V. M. Cheremshenko, N. L. Karaman, O. M. Chekhun, V. F. Свободных экз. нет |
Chekhun, V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical backlground) / V. F. Chekhun, E. A. Domina // Experimental Oncology. - 2021. - Том 43, N 3. - P277-280 MeSH-главная: КОРОНАВИРУСНЫЕ ИНФЕКЦИИ -- CORONAVIRUS INFECTIONS (осложнения) РАДИОТОЛЕРАНТНОСТЬ -- RADIATION TOLERANCE Аннотация: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Science of Ukraine has been studying the mechanisms and specificities of individual radiation sensitivity (IRS) formation in professionals who work in the field of ionizing radiation, cancer patients and representatives of other population groups. Our data based on the use of G2-test in in vitro irradiated blood lymphocytes in late G2-period of cell cycle indicated an increased carcinogenic risk in professionals with high IRS. We suggest that the COVID-19 pandemic could make significant adjustments in the formation of IRS in professionals who have survived the disease and continue to work with ionizing radiation (IR). Increased systemic inflammatory activity, which persists for a long time in COVID-19 patients, in combination with low-dose range irradiation (professionals who continue to work with IR) and with local irradiation in the high-dose range (radiation therapy for cancer patients) may affect IRS. Repeated determination of IRS in professionals who have had COVID-19 infection, using chromosomal G2-radiation sensitivity assay will answer the question: can SARS-CoV-2 coronavirus affect the IRS? The proposed hypothesis of the radiosensitivity evolution needs further experimental validation using a set of radiobiological indices to clarify the mechanism of IRS formation following COVID-19 infection. The detected changes (increase) of human IRS after COVID-19 must be taken into account for personalized planning of radiotherapy of COVID-19 cancer patients Доп.точки доступа: Domina, E. A. Свободных экз. нет |
Шифр: ЕУ12/2021/43/1 Журнал 2021г. Т. 43 № 1 . - 51.32, р. Cavalli, M. A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer / M. Cavalli [та ін.]. - С.2-7. - Bibliogr. at the end of the art. Другие авторы: Diamanti K.1., Pan G., Dabrowski M. J., Komorowski J., Wadelius C. Yakovlev, P. G. Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin / P. G. Yakovlev [та ін.]. - С.7-14. - Bibliogr. at the end of the art. Другие авторы: Gorbach O. I., Khranovska N. M., Beliayeva A. V., Skachkova O. V., Skaterna T. D., Kalachniuk L. G., Ostapchenko L. I., Garmanchuk L. V. Chumak, A. V. Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis / A. V. Chumak [та ін.]. - С.15-20. - Bibliogr. at the end of the art. Другие авторы: Fedosova N.I., Cheremshenko N. L., Symchych T. 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Moreno, M. An uncommon case of vulvar cancer metastatic to breast / M. Moreno [та ін.]. - С.92-95. - Bibliogr. at the end of the art. Другие авторы: Matschinski G. N., Czarnobai I., Oliveira A., Boff T. C. Ada Leonidivna Vorontsova (1934–2020). - С.96 Имеются экземпляры в отделах: всего 1 Свободны: 1 |