Шифр: УУ60/2017/89/5 Журнал 2017г. Т. 89 № 5 Mikosha, A. S. Biochemical mechanism of the o,p’-DDD effect on the adrenal cortex / A. S. Mikosha, О. I. Kovzun. - P.5-14 Osadchuk, T. V. Influence of cations on furin activity / T. V. Osadchuk [et al.]. - P.15-20 Другие авторы: Shybyryn O. V., Semyroz A. V., Bondarenko O. M., Kibirev V. K. Yatsenko, T. A. Ca2+-dependent regulation of fibrinolytic system activation on fibrin(ogen) D-domains / T. A. Yatsenko [et al.]. - P.21-31 Другие авторы: Rybachuk V. М., Kharchenko S. M., Grinenko T. V. Protopopov, M. V. Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives / M. V. Protopopov [et al.]. - P.32-39 Другие авторы: Ostrynska O. V., Ivanchenko D. H., Starosyla S. A., Bdzhola V. G., Romanenko M. I., Yarmoluk S. M. Minchenko, O. H. Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia / О. Н. Minchenko [et al.]. - P.40-51 Другие авторы: Luzina O. Y., Hnatiuk O. S., Minchenko D. O., Garmash I. A., Ratushna O. O. Halkin, O. V. Expression of ubiquitin specific peptidase and ATG7 genes in U87 glioma cells upon glutamine deprivation / O. V. Halkin [et al.]. - P.52-61 Другие авторы: Minchenko D. O., Riabovol O. O., Telychko V. V., Ratushna O. O., Minchenko O. H. Berdyshev, A. G. Modulation of LPS-induced ROS production and NF-кB nuclear translocation by N-stearoylethanolamine in macrophages / A. G. Berdyshev, H. V. Kosiakova, N. M. Hula. - P.62-69 Oriabinska, L. B. Ethylthiosulfanilate effect on Candida tropicalis / L. B. Oriabinska [et al.]. - P.70-76 Другие авторы: Starovoitova S. O., Vasylyuk S. V., Novikov V. P., Lubenets V. I. Kobylinska, L. I. Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity / L. I. Kobylinska [et al.]. - P.77-83 Другие авторы: Panchuk R. R., Lesyk R. B., Zimenkovsky B. S., Stoika R. S. Parkhomenko, Yu. M. Thiamine diphosphate synthesis and redox state indicator in the RAT brain during B1 hypovitaminosis / Yu. M. Parkhomenko [et al.]. - P.84-96 Другие авторы: Pavlova A. S., Mejenskaya O. A., Stepanenko S. P., Chekhivska L. I. Manoilov, K. Yu. Enhancement of internalization of diphtheria toxin recombinant fragments in sensitive cells mediated by toxin’s T-domain / K. Yu. Manoilov [et al.]. - P.96-105 Другие авторы: Labyntsev A. J., Korotkevych N. V., Kolybo D. V. Vovkun, T. V. The features of bile acids exchange in rats under the influence of corvitin / T. V. Vovkun [et al.]. - P.106-116 Другие авторы: Yanchuk P. I., Shtanova L. Ya., Veselskiy S. P., Filimonova N. B., Shalamay A. S., Vedmid V. G. Виноградова, Р. П. Науково-практична діяльність лабораторії сигнальних механізмів клітини Інституту біохімії ім. О. В. Палладіна НАН України / Р. П. Виноградова, І. Ю. Черниш, В. М. Данилова. - P.117-123 The Nobel Prize in Physiology or Medicine 2017. - P.127 The Nobel Prize in Chemistry 2017. - P.128 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Mikosha, A. S. Biochemical mechanism of the o,p’-DDD effect on the adrenal cortex / A. S. Mikosha, О. I. Kovzun // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 5. - P5-14 MeSH-главная: НАДПОЧЕЧНИКОВ КОРЫ БОЛЕЗНИ -- ADRENAL CORTEX DISEASES (терапия) НАДПОЧЕЧНИКОВ КОРА -- ADRENAL CORTEX (действие лекарственных препаратов) ГИПОФИЗАРНОГО АКТГ ГИПЕРСЕКРЕЦИЯ -- PITUITARY ACTH HYPERSECRETION (лекарственная терапия) ДИХЛОРДИФЕНИЛДИХЛОРЭТАН -- DICHLORODIPHENYLDICHLOROETHANE (терапевтическое применение, фармакокинетика) Аннотация: o,p’-Dichlorodiphenyldichloroethane (o,p’-DDD, mitotane) is used in the treatment of adrenocortical cancer and Cushing’s disease. This medicine induces numerous biochemical changes in the adrenal cortex, as well as disorder in the mitochondrial structure. Therewith, the level of produced corticosteroid hormones is significantly reduced. One of the possible causes can be a decrease in the NADPH level due to inhibition of the activity of its reduction system and increased NADPH consumption during the glutathione reduction catalyzed by glutathione reductase. o,p’-DDD is partially metabolized in the adrenal glands, and the main metabolite (in terms of quantity) is o,p’-dichlorodiphenylacetic acid. However, attempts to find a physiologically active component among metabolites were unsuccessful. The most pronounced changes caused by o,p’-DDD were found in the mitochondria of the adrenal cortex. The respiration at the level of IV and I complexes is suppressed, the protein content of these complexes decreases. The phospholipid composition of the tissue altered and the concentration of diphosphatidylglycerol, the most important component of mitochondrial membranes, decreased. In our opinion, o,p’-DDD, owing to its high lipophilicity, accumulates in the mitochondria membranes and causes conformational disorder followed by disorder in mitochondrial functions. It was shown that o,p’-DDD acts as an inhibitor of acyl-CoA-cholesterol acyltransferase (ACAT, SOAT1). Therefore, adenocorticocytes accumulate free cholesterol, causing endoplasmic reticulum stress, mitochondrial swelling and caspases activation. Increased apoptosis leads to a decline in adrenal function and to a decrease in weight of adrenal glands Доп.точки доступа: Kovzun, О. I. Свободных экз. нет |