Шифр: УУ60/2017/89/4 Журнал 2017г. Т. 89 № 4 Babenko, L. M. Lipoxygenase activity in ontogenesis of ferns Salvinia natans and Polystichum aculeatum / L. M. Babenko, T. D. Skaterna, I. V. Kosakivska. - P.5-12 Chekh, B. O. Characteristics of novel polymer based on pseudo-polyamino acids GluLa-DPG-PEG600: binding of albumin, biocompatibility, biodistribution and potential crossing the blood-brain barrier in rats / B. O. Chekh [et al.]. - P.13-21 Другие авторы: Ferens M. V., Ostapiv D. D., Samaryk V. Y., Varvarenko S. M., Vlizlo V. V. Palagina, I. A. Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives / I. A. Palagina. - P.22-33 Kolupaev, Yu. E. Induction of plant cells heat resistance by hydrogen sulfide donor is mediated by H2O2 generation with participation of NADPH oxidase and superoxide dismutase / Yu. E. Kolupaev, E. N. Firsova, T. O. Yastreb. - P.34-42 Khomochkin, A. P. Reversible pH-dependent activation/inactivation of CF1-ATPase of spinach chloroplasts / A. P. Khomochkin [et al.]. - P.43-48 Другие авторы: Onoiko O. B., Semenikhin A. V., Zolotareva O. K. Gozhenko, A. I. The experimental investigation of fibrinolytic system under the influence of flocalin in conditions of acute hypoxic kidney injury / A. I. Gozhenko [et al.]. - P.49-55 Другие авторы: Gubsky Yu. I., Filipets N. D., Filipets O. O., Gozhenko O. A. Prysiazhniuk, A. I. Role of peripheral dopaminergic system in the pathogenesis of experimental colitis in rats / A. I. Prysiazhniuk [et al.]. - P.56-67 Другие авторы: Rudyk M. P., Chervinska T. M., Dovbynchuk T. V., Opeida I. V., Skivka L. M., Tolstanova G. M. Horid’ko, T. M. Antistress effects of N-stearoylethanolamine in rats with chronic social stress / T. M. Horid’ko [et al.]. - P.68-76 Другие авторы: Kosiakova H. V., Berdyshev A. G., Meged O. F., Gudz E. A., Onopchenko O. V., Asmolkova V. S., Lozova V. M., Tukalenko E. V., Bondarenko O. V., Tubalzeva I. I., Kovalenko O. A., Makarchuk M. Y., Hula N. M. Subekti, N. Determination of the major compounds in the extract of the subterranean termite Macrotermes gilvus Hagen digestive tract by GC-MS method / N. Subekti [et al.]. - P.77-82 Другие авторы: Fibriana F., Widyaningrum P., Adfa M. Виноградова, Р. П. Науково-практичні розробки відділу молекулярної біології Інституту біохімії ім. О. В. Палладіна НАН України / Р. П. Виноградова, М. В. Григор’єва, В. М. Данилова. - P.83-90 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Palagina, I. A. Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives / I. A. Palagina // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 4. - P22-33 MeSH-главная: СУКЦИНАТЫ -- SUCCINATES (фармакокинетика) АЗОТА ОКСИДЫ -- NITROGEN OXIDES (метаболизм) Аннотация: The derivatives of a succinic acid represent active compounds which realize their biological action via the influence on pro-/antioxidant processes and energetic metabolism. We studied the nitrogen oxide metabolism as well as reactions of the proteins and lipids free-radical peroxide oxidation under a sub-chronic effect of anti-diabetically active compounds – succinic acid derivatives and its metabolites. We found that the studied compounds were able to change the intensity of protein- and lipoperoxidation in a liver and blood serum interconnected with changes in the activity of the key antioxidant enzymes. The derivatives of succinic acid proved to inhibit the nitrogen oxide synthase reflected in a decrease in nitrite- and nitrate-anion level in a liver, blood plasma and urine as well as in changes in the oxidation processes in a liver and blood serum. We concluded in stating that the specified changes of pro-/antioxidant and nitrogen oxide homeostasis may serve as assessment criteria of the succinate-containing compounds’ biological action Свободных экз. нет |