Шифр: ЕУ12/2020/42/1 Журнал 2020г. Т. 42 № 1 Bubnovskaya, L. Tumor microenvironment and metabolic factors: contribution to gastric cancer / L. Bubnovskaya, D. Osinsky. - С.2-10 Gong, Y. Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia / Y. Gong [et al.]. - С.11-15 Другие авторы: Wu J., Yang R., Zhang L., Ma Z. Shcherbina, V. Sensitivity of chronic lymphocytic leukemia cells to chemotherapeutic drugs ex vivo depends on expression staus of cell surface receptors / V. Shcherbina [et al.]. - С.16-24 Другие авторы: Gordiienko I., Shlapatska L., Ivanivska T., Sidorenko S. Siromolot, A. A. Antiproliferative and apoptotic effects of anti-human HB-EGF neutralizing polyclonal antibodies in vitro / A. A. Siromolot [et al.]. - С.25-30 Другие авторы: Krynina O. I., Kolybo D. V., Komisarenko S. V. Shvachko, L. P. Aberrant expression of placental-like alkaline phosphatase in chronic myeloid leukemia cells in vitro and its modulation by vitamin E / L. P. Shvachko [et al.]. - С.31-34 Другие авторы: Zavelevich M. P., Gluzman D. F., Telegeev G. D. Kolesnik, D. L. Metformin enhances cytotoxic action of dichloroacetate against lewis lung carcinoma cells in vitro / D. L. Kolesnik [et al.]. - С.35-39 Другие авторы: Pyaskovskaya O. N., Gorbach O., Solyanik G. I. Sarnatskaya, V. V. Structural changes of serum albumin in response to oxidative stress caused by Walker-256 carcinosarcoma growth / V. V. Sarnatskaya [et al.]. - С.40-45 Другие авторы: Yushko L. A., Prokopenko I. V., Hudenko N. V., Maslenny V. N., Paziuk L. M., Bubnovskaya L. N., Nikolaev V. G. Burlaka, A. A. Drag reducing polymers attenuate adverse effects of ischemia-reperfusion upon resection of liver metastases modeled by MC38 mouse colon adenocarcinoma / A. A. Burlaka [et al.]. - С.46-50 Другие авторы: Burlaka A. P., Krotevych M. S., Rudiuk T. O., Orel V. E. Lifsics, A. Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy / A. Lifsics [et al.]. - С.51-59 Другие авторы: Rate E., Ivanova A., Tars J., Murovska M., Groma V. Bilous, N. MYC copy number and mRNA expression in chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chornobyl NPP accident / N. Bilous [et al.]. - С.60-65 Другие авторы: Abramenko I., Chumak A., Dyagil I., Martina Z. Fedorenko, Z. P. Incidence and long-term effects of treatment of malignant germ cell neoplasms in Ukraine / Z. P. Fedorenko [et al.]. - С.66-74 Другие авторы: Mikchailovich Yu. I., Goulak L. O., Ryzhov A. Yu., Gorokh Ye. L., Soumkina O. V. Kozirovskis, V. High expression of GLI1 is associated with better survival in advanced SCLC / V. Kozirovskis [et al.]. - С.75-77 Другие авторы: Zandberga E., Magone M., Purkalne G., Line A., Vikmanis U. Kearney, L. Frequency and spectrum of atypical BCR-ABL1 transcripts in chronic myeloid leukemia / L. Kearney, M. Grampe, S. E. Langabeer. - С.78-79 In commemoration of Dmitriy Vladimirovich Myasoyedov. - С.80 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Шифр: ЕУ12/2021/43/2 Журнал 2021г. Т. 43 № 2 Vitruk, Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue / Yu. V. Vitruk [et al.]. - С.98-103 Другие авторы: Semko S. L., Voylenko O. A., Pikul M. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Stakhovsky E. O., Rossylna O. V. Pyaskovskaya, O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis / O. N. Pyaskovskaya [et al.]. - С.104-110 Другие авторы: Kolesnik D. L., Garmanchouk L. V., Yanish Yu. V., Solyanik G. I. Akalovich, S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression / S. Akalovich [et al.]. - С.111-117 Другие авторы: Portyanko A., Pundik A., Mezheyeuski A., Doroshenko T. Bychkov, V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines / V. A. Bychkov [et al.]. - С.118-124 Другие авторы: Pevzner A. M., Nebova J. A., Ermakova N. N., Ibragimova M. K., Tsyganov M. M., Lyapunova L. S., Litviakov N. V. Ayyildiz, A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells / A. Ayyildiz [et al.]. - С.125-134 Другие авторы: Koc H., Turkekul K., Erdogan S. Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko. - С.135-141 Yakovlev, P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage / P. G. Yakovlev [et al.]. - С.142-148 Другие авторы: Gorbach O. I., Ostapchenko L. I., Garmanchuk L. V., Skachkova O. V., Khranovska N. M., Senchylo N. V. Zoubi, M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population / M. S. Zoubi [et al.]. - С.149-154 Другие авторы: Al-Eitan L. N., Rababa D. M., Al-Batayneh K., Farzand R., Quinn G. A., Tambuwala M. M., Bakshi H. A. Kornatska, A. G. A variant of TP53 gene (RS 1625895, 13494G>A) is associated with neoplasm localization in patients with uterine leiomyoma / A. G. Kornatska [et al.]. - С.155-158 Другие авторы: Flaksemberg M. A., Chubei G. V., Trokhymovych O. V., Rossokha Z. I., Fishchuk L. Ye., Medvedieva N. L., Vershyhora V. O., Gorovenko N. G. Mohamed, Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review / A. A. Mohamed Yusoff [et al.]. - С.159-167 Другие авторы: Abd Radzak S. M., Mohd Khair S. Z. N., Abdullah J. M. Ben, Kridis W. Therapeutic results of laryngeal preservation: a retrospective study / W. Ben Kridis [et al.]. - С.168-172 Другие авторы: Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A. Pilinska, M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro / M. A. Pilinska [et al.]. - С.173-176 Другие авторы: Shemetun O. V., Talan O. O., Dibska O. B., Talko V. V. De, Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor / V. De Giorgi [et al.]. - С.177-179 Другие авторы: Venturi F., Portelli F., Maida P., Scarfi F., Trane L., Gori A., Silvestri F., Massi D. Liubota, R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases / R. Liubota [et al.]. - С.180-184 Другие авторы: Vereshchako R., Anikusko M., Liubota I., Vakulenko G. Pasichnyk, S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model / S. M. Pasichnyk [et al.]. - С.185-188 Другие авторы: Pasichnyk M. S., Lychkovsky A. E., Stakhovsky E. O., Gozhenko A. I., Shatnyi S. V., Pasichnyk M. A. Gluzman, D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects / D. F. Gluzman [et al.]. - С.189-192 Другие авторы: Zavelevich M. P., Philchenkov A. A., Koval S. V., Guslitser L. N., Zinchenko V. N., Bezhenar T. O. Имеются экземпляры в отделах: (23.05.2022г. Экз. 1 - Б.ц.) (свободен) |
Role of tumor/endothelial cell interactions in tumor growth and metastasis [Text] / O. N. Pyaskovskaya [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P104-110 MeSH-главная: КЛЕТОК ТРАНСФОРМАЦИЯ НЕОПЛАСТИЧЕСКАЯ -- CELL TRANSFORMATION, NEOPLASTIC (метаболизм, патология) ЭНДОТЕЛИАЛЬНЫЕ КЛЕТКИ -- ENDOTHELIAL CELLS (патология) НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (патофизиология) Аннотация: It is known that interactions between tumor and endothelial cells have a significant influence on the growth and metastasis of malignant tumors. Aim: To study the reciprocal effect of Lewis lung carcinoma (LLC) and endothelial cells on the growth rate of each other upon their co-cultivation in vitro and to assess the contribution of such tumor/endothelial cell crosstalk to in vivo LLC growth and metastasis. Materials and Methods: Two variants of Lewis lung carcinoma cells, high-metastatic (LLC) and low-metastatic (LLC/R9), and murine aorta endothelial cell line (MAEC) were used. Kinetics of tumor cell growth in vitro and in vivo, electrokinetic properties of tumor cells and their adhesion to endothelial monolayer, and the number of tumor and endothelial viable cells after 1-day contact or non-contact co-cultivation were estimated. Results: LLC/R9 had significantly higher growth rate in vivo (as opposed to in vitro) than LLC. However, the number and volume of lung metastatic lesions in LLC/R9-bearing mice were 4.5-fold (p 0.05) and 3.6-fold lower (p 0.05), respectively, compared to those in LLC-bearing mice. Non-contact co-cultivation of LLC/R9 + MAEC caused more than a 34% (p 0.05) LLC/R9-induced increase in the number of MAEC and a 60% (p 0.05) MAEC-induced increase in the number of LLC/R9 cells as compared to those of corresponding controls (cells cultured alone). In contrast, in the case of LLC + MAEC, both the number of LLC and MAEC cells after their non-contact co-cultivation and cultivation alone did not differ significantly. Contact co-cultivation LLC+MAEC (in contrast to LLC/R9+MAEC) caused more than a 50% (p 0.01) LLC-induced decrease in the number of MAEC and a 50% decrease (p 0.05) MAEC-induced in the number of LLC cells as compared to the corresponding controls. Both tumor cell variants showed a bimodal distribution of cells by ζ-potential, but in the case of LLC there was observed a shift towards high values due to 52% of cells with a surface charge density 10 C/m2, while in the case of LLC/R9 such a subpopulation was absent and 19% of cells had a surface charge 5 C/m2. The number of LLC cells that adhered to the monolayer of endothelial cells was by 65% (p 0.05) higher than that of LLC/R9 cells. Conclusion. Obtained data demonstrated that the tumor/endothelial cell relationships might reflect the features of tumor growth and metastasis of a malignant tumor Доп.точки доступа: Pyaskovskaya, O. N. Kolesnik, D. L. Garmanchouk, L. V. Yanish, Yu. V. Solyanik, G. I. Свободных экз. нет |
Шифр: ЕУ12/2021/43/3 Журнал 2021г. Т. 43 № 3 To the thirties anniversary of the independence of Ukraine priorities in cancer research: retrospective and prospective aspects. - С.194-196 Chumak, A. V. Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma / A. V. Chumak [et al.]. - С.197-203 Другие авторы: Fedosova N. I., Shcherbina V. M., Cheremshenko N. L., Karaman O. M., Chekhun V. F. Kovalevska, L. M. Expression pattern of MRPS 18 family genes in gliomas / L. M. Kovalevska [et al.]. - С.204-208 Другие авторы: Malysheva T. A., Kalman S. S., Rozumenko A. V., Verbova L. V., Rozumenko V. D., Kashuba E. V. Roomi, M. W. A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells IN VIVO and IN VITRO by inhibiting MMPS and inducing apoptosis / M. W. Roomi [et al.]. - С.209-216 Другие авторы: Bhanap B., Niedzwiecki A., Rath M. Khranovska, N. Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy / N. Khranovska [et al.]. - С.217-223 Другие авторы: Shachkova O., Gorbach O., Inomistova M., Orel V. Abramenko, I. Association of lipoprotein lipase expression with TP53 gene polymorphisms in chronic lymphocytic leukemia cells / I. Abramenko [et al.]. - С.224-228 Другие авторы: Bilous N., Chumak A., Dyagil I., Martina Z. Zotova, O. V. 11q23/MLL rearrangements in adult acute leukemia / O. V. Zotova [et al.]. - С.229-233 Другие авторы: Lukianova A. S., Valchuk M. O., Karol Yu. S., Dhalay O. O., Novak V. L., Loginsky V. E. Horacek, J. M. Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival / J. M. Horacek [et al.]. - С.234-236 Другие авторы: Kupsa T., Vanek J., Jakl M., Stajer M., Jebavy L., Zak P. Konovalenko, V. F. Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal / V. F. Konovalenko [et al.]. - С.237-241 Другие авторы: Ternovyi N. K., Tuz E. V., Protsenko V. V., Solonitsyn E. O., Udai A., Drobotun O. V., Ulianchych N. V. Ivankova, V. S. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients / V. S. Ivankova [et al.]. - С.242-246 Другие авторы: Domina E. A., Khrulenko T. V., Makovetska L. I., Hrinchenko O. O., Baranovska L. M. Rawoot, S. Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know? / S. Rawoot [et al.]. - С.247-251 Другие авторы: Punatar C., Singh V., Anand A., Shah B., Nagaonkar S., Joshi V. Vlachou, M. S. Plasma ctDNA ras status selects patients for anti-EGER treatment rechallenge in metastatic colorectal cancer: a meta-analysis / M. S. Vlachou [et al.]. - С.252-256 Другие авторы: Mauri D., Zarkavelis G., Ntellas P., Tagkas C., Gkoura S., Pentheroudakis G. Kukushkina, M. Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors / M. Kukushkina [et al.]. - С.252-260 Другие авторы: Korovin S., Diedkov S., Ostafiichuk V., Diedkov A. Burlaka, A. P. Redox dependent features of tumors, adipose tissue. neutrophiles and platelets in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.261-265 Другие авторы: Virko S. V., Burlaka A. A., Krupnyk K. L. Kornatska, A. G. ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopapthy in infertile women / A. G. Kornatska [et al.]. - С.266-269 Другие авторы: Rossokha Z. I., Fishchuk L. Ye., Dubenko O. D., Medvedieva N. I., Haksemberg M. A., Chubei G. V., Popova O. F., Gorovenko N. G. Solyanik, G. I. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma / G. I. Solyanik [et al.]. - С.270-276 Другие авторы: Karaman O. M., Yakshibaeva Y. R., Pyaskovskaya O. N., Kolesnyk D. I. Chekhun, V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background) / V. F. Chekhun, E. A. Domina. - С.277-280 Имеются экземпляры в отделах: Экз. 1 (свободен) |
Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma / G. I. Solyanik [et al.] // Experimental Oncology. - 2021. - Том 43, N 3. - P270-276 MeSH-главная: КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG (лекарственная терапия) МАКРОФАГИ -- MACROPHAGES (действие лекарственных препаратов) Аннотация: Inhibition of aerobic glycolysis of cancer cells is considered a promising therapeutic strategy for the treatment of neoplasms. Some inhibitors of energy metabolism can affect not only tumor cells but also the functional polarization of tumor-associated macrophages, which may either enhance the antitumor effect of such agents or impair their antitumor efficacy. Aim: To investigate the effect of oxamate, a lactate dehydrogenase (LDH) inhibitor, on the polarization of peritoneal macrophages (PMP) in both intact mice and mice with transplanted Lewis lung carcinoma (LLC). Materials and Methods: The low-metastatic LLC variant, LLC/R9, was transplanted to female C57Bl/6 mice. Sodium oxamate was used as the test agent at concentrations of 0.02, 0.2, and 2 mg/ml. Macrophage polarization in tumor-bearing mice was estimated on day 23 after tumor transplantation by assessing nitric oxide (NO) production and arginase activity as functional indices of PMPs polarization. Results: Oxamate can affect the functional polarization of PMPs in both intact mice and animals with transplanted LLC/R9. Oxamate in all studied concentrations changed the markers of PMPs polarization in intact mice (decreasing NO levels and activating arginase activity) that indicated the stimulation of M2 polarization. In tumor-bearing animals, stimulation of M2 polarization is observed at low concentrations of oxamate (0.02 mg/ml), but its high concentrations (2.0 mg/ml) causes M1 polarization, which is characterized by three-fold increase in the level of NO and a decrease in the level of arginase activity. Conclusion: Oxamate, an inhibitor of LDH, can stimulate M2 polarization of peritoneal macrophages of mice bearing LLC in a dose-dependent manner Доп.точки доступа: Solyanik, G. I. Karaman, O. M. Yakshibaeva, Y. R. Pyaskovskaya, O. N. Kolesnyk, D. I. Свободных экз. нет |
Шифр: ЕУ12/2021/43/1 Журнал 2021г. Т. 43 № 1 . - 51.32, р. Cavalli, M. A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer / M. Cavalli [та ін.]. - С.2-7. - Bibliogr. at the end of the art. Другие авторы: Diamanti K.1., Pan G., Dabrowski M. J., Komorowski J., Wadelius C. Yakovlev, P. G. Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin / P. G. Yakovlev [та ін.]. - С.7-14. - Bibliogr. at the end of the art. Другие авторы: Gorbach O. I., Khranovska N. M., Beliayeva A. V., Skachkova O. V., Skaterna T. D., Kalachniuk L. G., Ostapchenko L. I., Garmanchuk L. V. Chumak, A. V. Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis / A. V. Chumak [та ін.]. - С.15-20. - Bibliogr. at the end of the art. Другие авторы: Fedosova N.I., Cheremshenko N. L., Symchych T. V., Voyeykova I. M., Chekhun V. F. Yushko, L. A. Comparative study of biochemical and morphological parameters in rats with Walker 256 and Walker 256/DOX carcinosarcoma / L. A. Yushko [та ін.]. - С.21-25. - Bibliogr. at the end of the art. Другие авторы: Sarnatskaya V. V., Sakhno L. A., Hudenko N. V., Paziuk L. M., Maslenny V. N., Melnyk V. O., Nikolaev V. G. Prokhorova, I. V. ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin / I. V. Prokhorova [та ін.]. - С.26-30. - Bibliogr. at the end of the art. Другие авторы: Gorbach O. I., Yakshibaeva Yu. R., Shliakhtova N. А., Solyanik G. I. Elemam, O. Emergency oncology admissions during COVID-19 pandemic: a major institution experience from Saudi Arabia / O. Elemam [та ін.]. - С.31-35. - Bibliogr. at the end of the art. Другие авторы: Tashkandi E., Abdelkhalek S., Shalaby I., Baraka R. Kravets, O. V. Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity / O. V. Kravets [та ін.]. - С.36-40. - Bibliogr. at the end of the art. Другие авторы: Burtyn O. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Kolesnik O. O. Boyko, O. Erythropoietin as an independent prognostic factor in myelodysplastic syndromes / O. Boyko [та ін.]. - С.41-45. - Bibliogr. at the end of the art. Другие авторы: Simonova M., Knysh N., Danysh O., Vygovska Y., Masliak Z. Samoylenko, О. А. Ornithine decarboxylase activity in prostate cancer / О. А. Samoylenko [та ін.]. - С.46-51. - Bibliogr. at the end of the art. Другие авторы: Stakhovsky E. O., Vitruk Y. V., Shlyakhovenko V. O. Gervas, P. New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients / P. Gervas [та ін.]. - С.52-55. - Bibliogr. at the end of the art. Другие авторы: Molokov A., Ivanova A., Panferova Ye., Kiselev A., Chernyshova A., Pisareva L., Choynzonov E., Cherdyntseva N. Lobanova, O. E. Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue / O. E. Lobanova [та ін.]. - С.56-60. - Bibliogr. at the end of the art. Другие авторы: Rossokha Z. I., Medvedieva N. L., Cheshuk V. E., Vereshchako R. I., Vershyhora V. O., Fishchuk L. Ye., Zakhartseva L. M., Gorovenko N. G. Hergebue, K. Therapeutic results and prognostic factors of stage III NSCLC: a population-based study in Tunisia / K. Hergebue [та ін.]. - С.61-66. - Bibliogr. at the end of the art. Другие авторы: Mejri N., Berrazega Y., Rachdi H., El Benna H., Labidi S., Boussen H. Tsip, N. P. Experience with the use of HIPEC in advanced serous ovarian cancer after complete and optimal cytoreduction / N. P. Tsip [та ін.]. - С.67-72. - Bibliogr. at the end of the art. Другие авторы: Kopetskiy V. I., Polentsov Yu. O., Yegorov M. Yu., Vakulenko G. O., Svintsitskiy V. S. Gurianov, D. S. Nuclear localization of BCR and cortactin indicates their potential role in regulation of actin branching in nucleus / D. S. Gurianov, S. V. Antonenko, G. D. Telegeev. - С.73-76. - Bibliogr. at the end of the art. Yanish, Yu. V. Application of gold and silver nanoparticles for selective assay of spermine in mixture with spermidine / Yu. V. Yanish [та ін.]. - С.77-81. - Bibliogr. at the end of the art. Другие авторы: Zaletok S. P., Vityuk N. V., Mukha Yu. P. Drogovoz, S. M. Experience and prospects for the use of off-label drugs in oncology / S. M. Drogovoz [та ін.]. - С.82-86. - Bibliogr. at the end of the art. Другие авторы: Starikov V. I., Ivantsyk L. B., Shchokina K. G. Gluzman, D. F. Immunodeficiency-associated lymphoproliferative disorders and lymphoid neoplasms in post-COVID-19 pandemic era / D. F. Gluzman [та ін.]. - С.87-91. - Bibliogr. at the end of the art. Другие авторы: Zavelevich M. P., Philchenkov A. A., Koval S. V., Bezhenar T. O. Moreno, M. An uncommon case of vulvar cancer metastatic to breast / M. Moreno [та ін.]. - С.92-95. - Bibliogr. at the end of the art. Другие авторы: Matschinski G. N., Czarnobai I., Oliveira A., Boff T. C. Ada Leonidivna Vorontsova (1934–2020). - С.96 Имеются экземпляры в отделах: всего 1 Свободны: 1 |
ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin [Text] = Продукція афк циркулюючими фагоцитами і резистентність карциноми Герена до цисплатину / I. V. Prokhorova [та ін.] // Экспериментальная онкология. - 2021. - Т. 43, № 1. - P26-30. - Bibliogr. at the end of the art. MeSH-главная: ЦИСПЛАТИН -- CISPLATIN (анализ, фармакокинетика) КАРЦИНОМА -- CARCINOMA (лекарственная терапия) ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM ФАГОЦИТЫ -- PHAGOCYTES БИОЛОГИЧЕСКИЕ МАРКЕРЫ -- BIOLOGICAL MARKERS (химия) Аннотация: Tumor drug resistance remains a primary cause of unsuccessful cancer therapy. The search for biological markers of the sensitivity/resistance of malignant neoplasms to drug therapy is an urgent and important task, the solution of which will increase the effectiveness of anticancer chemotherapy. Aim: To study the relationship between the functional activity (parameters of the phagocytosis and reactive oxygen species (ROS) production) of neutrophils and monocytes in the peripheral blood of rats with transplanted Guerin carcinoma and the degree of its sensitivity to cisplatin (Cpt). Materials and Methods: The original and Cpt-resistant variants of Guerin carcinoma were transplanted to female Wistar rats 2.5 months old. The parameters of the phagocytic activity of circulating neutrophils and monocytes were determined by the degree of ingestion of inactivated and FITC-labeled staphylococci using flow cytometry. The number of ROS-generating cells and the intensity of ROS production by phagocytes were determined by flow cytometry using 2’,7’-dichlorodihydrofluorescein diacetate. Results: The growth of both variants of Guerin carcinoma caused a statistically significant decrease in the intensity of neutrophil phagocytosis by more than 47% with a tendency to the reduction of the intensity of phagocytosis by monocytes. The phagocytic activity of circulating neutrophils and monocytes did not differ significantly between the groups of animals with the original and Cpt-resistant variant of Guerin carcinoma. In contrast, the intensity of ROS generation by both monocytes and neutrophils in the peripheral blood of animals with Cpt-resistant tumor increased by more than 86% as compared to original carcinoma-bearing rats. Conclusion: This study provides evidence that the intensity of ROS production by circulating monocytes and neutrophils may reflect the degree of tumor sensitivity to Cpt. Increased intensity of ROS production could serve as a pretreatment predictor of the formation of tumor drug resistance На сьогодні резистентність до протипухлинних препаратів залишається основною причиною безуспішної терапії раку. Тому пошук біологічних маркерів чутливості/резистентності злоякісних новоутворень до медикаментозної терапії є актуальним і важливим завданням, вирішення якого підвищить ефективність протипухлинної хіміотерапії. Метою роботи було вивчення взаємозв’язку між функціональною активністю (показниками фагоцитозу та продукцією АФК) нейтрофілів та моноцитів у периферичній крові щурів з перещепленою карциномою Герена та ступенем чутливості цієї пухлини до дії цисплатину. Матеріали та методи: Вихідний та резистентний до цисплатину варіанти карциноми Герена перещеплювали щурам-самкам лінії Wistar віком 2.5 міс. Оцінку фагоцитуючої активності циркулюючих нейтрофілів та моноцитів проводили на проточному цитометрі з використанням інактивованого Staphylococcus aureus, міченого флуоресцеїн ізотіоціонатом. Відносну кількість АФК-генеруючих клітин та інтенсивність продукції АФК фагоцитами крові визначали з використанням 2’,7’-дихлордигідрофлуоресцеїн діацетату методом проточної цитометрії. Результати: Ріст обох варіантів карциноми Герена супроводжується статистично достовірним зниженням інтенсивності фагоцитозу нейтрофілами більш ніж на 47%. Відзначається також тенденція до зниження інтенсивності фагоцитозу моноцитами. Фагоцитуюча активність циркулюючих нейтрофілів та моноцитів суттєво не відрізнялася між групами тварин з чутливим та резистентним до цисплатину варіантами карциноми Герена. На відміну від фагоцитуючої активності, дослідження виявило очевидну залежність між ступенем чутливості/резистентності карциноми Герена до дії цисплатину та інтенсивністю продукції АФК як моноцитами, так і нейтрофілами в периферичній крові тварин-пухлиноносіїв, рівень яких підвищився більш ніж на 86% у тварин з резистентним до цисплатину варіантом пухлини порівняно з таким у щурів з вихідним варіантом карциноми. Висновок: Інтенсивність продукції АФК моноцитами та нейтрофілами периферичної крові може відображати ступінь чутливості пухлини до дії цисплатину, а підвищення цих показників можна розглядати як предиктор формування резистентності пухлини до медикаментозного лікування Доп.точки доступа: Prokhorova, I. V. Gorbach, O. I. Yakshibaeva, Yu. R. Shliakhtova, N. А. Solyanik, G. I. Свободных экз. нет |
Шифр: ЕУ12/2017/39/4 Журнал 2017г. Т. 39 № 4 . - 34.76, р. Liubich, L. D. TGF-β1 expression by glioma C6 cells in vitro / L. D. Liubich [та ін.]. - С.258-263. - Bibliogr. at the end of the art. Другие авторы: Kovalevska L. M., Lisyany M. I., Semenova V. M., Malysheva T. A., Stayno L. P., Vaslovych V. V. Pyaskovskaya, O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo / O. N. Pyaskovskaya [та ін.]. - С.264-268. - Bibliogr. at the end of the art. Другие авторы: Kolesnik D. L., Fedorchuk A. G., Gorbik G. V., Solyanik G. I. Herrera-Covarrubias, D. Stress during puberty facilitates precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.269-275. - Bibliogr. at the end of the art. Другие авторы: Coria-Avila G. A., Hernandez M. E., Ismail N. Caballero-Hernandez, D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure / D. Caballero-Hernandez [та ін.]. - С.276-280. - Bibliogr. at the end of the art. Другие авторы: Najera-Valderrabano D., Valadez-Lira A., Franco-Molina M., Gomez-Flores R., Tamez-Guerra P., Tamez-Guerra R., Rodriguez-Padilla C. Bebeshko, V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals / V. Bebeshko, I. Homolyako, V. Grynchyshyn. - С.281-285. - Bibliogr. at the end of the art. Matveeva, A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells / A. Matveeva [та ін.]. - С.286-290. - Bibliogr. at the end of the art. Другие авторы: Kovalevska L., Kholodnyuk I., Ivanivskaya T., Kashuba E. Gordiienko, I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells / I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk. - С.291-298. - Bibliogr. at the end of the art. Buchynska, L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay / L. G. Buchynska [та ін.]. - С.299-303. - Bibliogr. at the end of the art. Другие авторы: Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V. Dumanskiy, Y. V. Adsorption-rheological properties of blood serum in lung cancer patients / Y. V. Dumanskiy [та ін.]. - С.304-307. - Bibliogr. at the end of the art. Другие авторы: Stoliarova O. Y., Syniachenko O. V., Giulmamedova M. F., Potapov Y. A. Skrypnyk, I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia / I. Skrypnyk [та ін.]. - С.308-311. - Bibliogr. at the end of the art. Другие авторы: Maslova G., Lymanets T., Gusachenko I. Buchynska, L. G. Phenotypic features of endometrial tumors in patients with family history of cancer / L. G. Buchynska [та ін.]. - С.312-318. - Bibliogr. at the end of the art. Другие авторы: Lurchenko N. P., Glushchenko N. M., Nesina I. P. Patial, T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor / T. Patial [та ін.]. - С.319-321. - Bibliogr. at the end of the art. Другие авторы: Sharma K., Thakur D., Gupta G. Volodymyr Serhiiovych Mosiienko (1934–2017). - С.322 Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo [Текст] / O. N. Pyaskovskaya [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 264-268. - Bibliogr. at the end of the art. Аннотация: It is known that metformin is a hypoglycemic drug used to treat type II diabetes mellitus. Recently active studies of its antitumor activity in relation to different types of malignant cells are conducted. Aim: To determine the relationship between cytotoxic activity of metformin in vitro and its antitumor activity in vivo. Materials and Methods: The rat C6 glioma cell line and mouse Lewis lung carcinoma cells (LLC) were used in this work. The number of living cells in the cytotoxic test was evaluated using sulforhodamine B. Parameters of tumor cell susceptibility to metformin activity in vitro were calculated using nonlinear and linear regression of experimental data. The antitumor action of metformin in vivo was evaluated routinely by the extension of survival time (ST) (in rats with intracerebral C6 glioma) and its effect on the volume of the primary tumor, the number and volume of metastases (in mice with LLC). Results: In cultured LLC cells in vitro, the proportions of metformin-resistant (A₁, %) and metformin-sensitive (A₂, %) subpopulations were 10.0 ± 2.2% and 92.0 ± 3.5%, respectively, in terms of the total number of living cells. Parameter t, which characterizes the sensitivity of cancer cells to metformin action (the lower is the value of this parameter the higher is sensitivity of cells to metformin cytotoxicity), for metformin-resistant and metformin-sensitive subpopulations was: t1(mM) = ∞ and t2(mM) = 2.9 ± 0.3, correspondingly. For metformin-sensitive subpopulation of LLC cells IC₅₀ (mM) = 2.42 ± 0.34. The volume of the primary tumor, the amount and volume of metastases in mice receiving metformin at a dose of Dmin (0.15 g/kg) and Dmax (0.3 g/kg) values did not significantly differ from those in the control. However, in the case of Dmin, there was a tendency to increased volume of the primary tumor, in the case of Dmax, there was a tendency to increased volume of metastases. The analogical parameters (A₁, A₂, b₁, b₂, IC₅₀ (1), IC₅₀ (2)) characterizing cell sensitivity to the action of metformin in vitro were obtained in relation to C6 glioma cells. In metformin-resistant subpopulation, these parameters were: A₁ (%) = 72.3 ± 1.4; b1 (%/mM) = 0.43 ± 0.005; IC₅₀ (1) (mM) = 84.1 ± 2.4. For metformin-sensitive subpopulation, these parameters were: A₂ (%) = 30.8 ± 2.3; b2 (%/mM) = 2.87 ± 0.4; IC₅₀ (2) (mM) = 5.37 ± 0.45. In vivo, a statistically significant anti-glioma effect of metformin was observed: at a dose of Dmax (5.2 g/kg) administration of this preparation resulted in a prolongation of the mean ST of tumor-bearing rats by 23% (p 0.05) compared with that in the control. Conclusions: We found no correlation between the cytotoxic/cytostatic action of metformin in vitro and its antitumor activity in vivo on the two types of tumor cells; these results indicate a significant contribution of the tumor microenvironment to the implementation of the antitumor activity of the drug Доп.точки доступа: Pyaskovskaya, O. N. Kolesnik, D. L. Fedorchuk, A. G. Gorbik, G. V. Solyanik, G. I. Свободных экз. нет |
Шифр: ЕУ12/2018/40/3 Журнал 2018г. Т. 40 № 3 Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art. Другие авторы: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S. Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art. Другие авторы: Lukianova N. Y., Borikun T. V., Chekhun V. F. Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art. Другие авторы: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B. Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art. Другие авторы: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B. Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art. Другие авторы: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu. Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art. Другие авторы: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I. Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art. Другие авторы: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V. Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art. Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art. Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art. Другие авторы: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M. Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art. Другие авторы: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H. Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art. Другие авторы: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu. Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art. Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art. Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253 Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255 Yurii Yosypovych Kudryavets (1946–2018). - С.256-257 Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 [Текст] / I. V. Prokhorova [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 205-210. - Bibliogr. at the end of the art. Аннотация: The efficacy of antimetabolic therapy of malignant neoplasms could not be explained solely by the direct mechanisms of action of such energy metabolism inhibitors as sodium dichloroacetate (DCA) and metformin (MTF). The indirect effects of DCA and MTF on the organs and tissues, which could play significant role in the antitumor activity of these agents, have not been thoroughly explored. Aim: To investigate the effect of MTF, DCA and their combination on the survival of rats with C6 glioma and major haematological and biochemical blood parameters. Materials and Methods: DCA and MTF were administered orally to inbred female rats for 11 days starting from the second day after tumor cell transplantation at a total dose of 1.1 and 2.6 g/kg, respectively. When combined treatment was used, MTF was administered 3 hours after the administration of DCA. The content of lactate and pyruvate in blood plasma was determined on the ChemWell® 2910 (Combi) automatic analyzer. Blood parameters were determined using the Particle Counter PCE-210 automatic hematology analyzer. Results: The administration of DCA did not significantly affect the life span of rats with C6 glioma. Duration of life of rats, which were administered with MTF only, was significantly higher (by 19.1%, p 0.01). Combined administration of DCA + MTF prolonged life span of animals with glioma by 50% (p 0.001). The positive result of antitumor activity of MTF alone and in combination with DCA correlated with a decrease in the mean platelet volume/platelet count (MPV/PLT) ratio by 75.0% (p 0.05) compared with tumor control. In addition, the expressed antitumor effect of combination therapy with DCA and MTF was associated with a decrease (p 0.05) in glucose and lactate levels in blood plasma of rats with C6 glioma by 10% and 41.4%, respectively, compared to tumor control. Analysis of blood parameters showed that the growth of C6 glioma was accompanied by the development of leukopenia, anemia and thrombocytopenia. The introduction of DCA caused the correction of manifestations of anemia and leukopenia, but did not affect the level of platelets in the blood of animals with glioma. MTF alone and in combination with DCA positively influenced the number of white blood cells and caused complete thrombocytopenia correction, increasing platelet count by more than 200% (p 0.001). Conclusion: The ability of MTF either used alone or in combination with DCA to influence the development of C6 glioma which is manifested in an increase in the lifespan of rats has been revealed. The most pronounced antitumor effect was recorded against the background of the combined use of these agents, which may be due to their ability to lower the levels of lactate and glucose in the blood of tumor-bearing rats. It is proved that MTF both in monotherapy and in combination with DCA provides correction of anemia and thrombocytopenia, which arise at the background of glioma C6 growth. Key Words: sodium dichloroacetate, metformin, C6 glioma, hematological indices, lactate, glucose Доп.точки доступа: Prokhorova, I. V. Pyaskovskaya, O. N. Kolesnik, D. L. Solyanik, G. I. Свободных экз. нет |
Шифр: ЕУ12/2019/41/1 Журнал 2019г. Т. 41 № 1 . - 45.41, р. Solyanik, G. I. Quinazoline compounds for antitumor treatment / G. I. Solyanik. - С.3-6. - Bibliogr. at the end of the art. Mahmoudian, J. Expression profiling of plac1 in murine cancer cell lines / J. Mahmoudian [та ін.]. - С.7-13. - Bibliogr. at the end of the art. Другие авторы: Ghods R., Nazari M., Jeddi-Tehrani M., Ghahremani M. H., Ostad S. N., Zarnani A. H. Kolesnik, D. L. Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma / D. L. Kolesnik [та ін.]. - С.14-19. - Bibliogr. at the end of the art. Другие авторы: Pyaskovskaya O. N., Yakshibaeva Yu. R., Solyanik G. I. Lozovska, Yu. V. The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma / Yu. V. Lozovska [та ін.]. - С.20-25. - Bibliogr. at the end of the art. Другие авторы: Andrusishina I. M., Lukianova N. Yu., Burlaka A. P., Naleskina L. A., Todor I. N., Chekhun V. F. Burlaka, A. A. DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor / A. A. Burlaka [та ін.]. - С.26-31. - Bibliogr. at the end of the art. Другие авторы: Vovk A. V., Burlaka A. P., Kolesnik O. O. Stakheyeva, M. Integral characteristic of the immune system state predicts breast cancer outcome / M. Stakheyeva [та ін.]. - С.32-38. - Bibliogr. at the end of the art. Другие авторы: Eidenzon D., Slonimskaya E., Patysheva M., Bogdashin I., Kolegova E., Grigoriev E., Choinzonov E., Cherdyntseva N. Bilous, N. Analysis of LPL gene expression in patients with chronic lymphocytic leukemia / N. Bilous [та ін.]. - С.39-45. - Bibliogr. at the end of the art. Другие авторы: Abramenko I., Chumak A., Dyagil I., Martina Z. Alghamdi, S. Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions / S. Alghamdi, A. Tajaldeen. - С.46-52. - Bibliogr. at the end of the art. Poluben, L. Copy number alterations and copy-neutral loss of heterozygosity in Ukrainian patients with primary myelofibrosis / L. Poluben [та ін.]. - С.53-56. - Bibliogr. at the end of the art. Другие авторы: Bryke Ch. R., Hsu Y., Shumeiko O., Neumerzhitska L., Klimuk B., Rybchenko L., Klymenko S., Balk S. P., Fraenkel P. G. Bakai, O. A. Radiation research to determine local tumor invasion in patients with cervical cancer / O. A. Bakai [та ін.]. - С.57-60. - Bibliogr. at the end of the art. Другие авторы: Golovko T. S., Ganich A. V., Gavriluk O. N., Ashykhmin A. V. Zabolotnyi, D. I. Aggregated proteins in malignant and benign neoplasms / D. I. Zabolotnyi [та ін.]. - С.61-68. - Bibliogr. at the end of the art. Другие авторы: Belousova A. A., Zabolotna D. D., SavchenkoT. D., Voroshylova N. M., Timchenko M. D., Tsvirinko I. R., Verevka S. V. Shirin, V. Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients / V. Shirin [та ін.]. - С.69-71. - Bibliogr. at the end of the art. Другие авторы: Sayfidin J., Mina E. -R., Shohren K., Reza S. Tkachenko, R. Parathyroid carcinoma: a case report / R. Tkachenko [та ін.]. - С.72-75. - Bibliogr. at the end of the art. Другие авторы: Zakhartseva L., Golovko A., Golovko A., Kuryk O., Lazarenko G. Semko, S. A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach / S. Semko [та ін.]. - С.76-79. - Bibliogr. at the end of the art. Другие авторы: Pikul M., Voylenko O., Stakhovskyi O., Kononenko O., Vitruk Yu., Stakhovsky E. De, Giorgi V. Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study / Giorgi V. De [та ін.]. - С.80-81. - Bibliogr. at the end of the art. Другие авторы: Scarfì F., Silvestri F., Maida P., Gori A., Trane L., Massi D. Langabeer, S. E. Suboptimal molecular response to tyrosine kinase inhibition associated with acquisition of a T240A ABL1 kinase domain mutation in a patient with chronic myeloid leukemia / S. E. Langabeer [та ін.]. - С.82-83. - Bibliogr. at the end of the art. Другие авторы: Haslam K., Crampe M., MacDonagh B., McHugh J. Brieieva, O. Scientific and Practical Conference of Young Scientists “Fundamental Medicine: Integrated Approaches to Cancer Therapy” / O. Brieieva. - С.84-86. - Bibliogr. at the end of the art. Tumor and Host: Novel Aspects of Old Problem. - С.87 Ludmyla Zakharivna Polishchuk (1937–2019). - С.88 Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Solyanik, G. I. Quinazoline compounds for antitumor treatment [Текст] / G. I. Solyanik // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 3-6. - Bibliogr. at the end of the art. Аннотация: Quinazolines are among the most useful heterocyclic compounds due to their diverse chemical reactivity and a wide range of biological activity. Despite a large number of publications devoted to quinazolines and their derivatives, information is presented predominantly regarding the features of the synthesis of these compounds and their structure. The studies of specific pharmacological activity and antitumor activity of these compounds are mainly limited to primary screening using enzyme systems and cell lines. In this mini review information concerning the potential targets for antitumor action of quinazoline compounds is summarized and discussed Свободных экз. нет |
Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma [Текст] / D. L. Kolesnik [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 14-19. - Bibliogr. at the end of the art. Аннотация: The use of inhibitors of energy metabolism of malignant cells is a new promising trend in the treatment of cancer patients, based on one of the unique features of the malignant cell, namely the dominance of glycolysis over oxidative phosphorylation, even in the presence of oxygen, the so-called Warburg effect. Aim: To study time-dependent cytotoxicity of sodium dichloroacetate (DCA) and metformin (MTF) against metastatic tumor cells and action of these agents on tumor cell migration. Materials and Methods: In the study low metastatic LLC/R9 variant of Lewis lung carcinoma was used. The number of living cells in the cytotoxic test was evaluated using sulforhodamine B after 1, 2 and 3 days of cell incubation in vitro. The parameters of the sensitivity of tumor cells to the action of DCA and MTF in vitro were calculated using nonlinear and linear regression of experimental data. The effect of DCA and MTF on cellular motility in vitro was evaluated using a Boyden chamber by calculation of the number of cells that migrated to the bottom side of the filter within 3 days of incubation. The statistical analysis of the data was carried out with the use of descriptive methods, Student’s t-criterion, nonlinear, and linear regression analysis. Results: IC50 of DCA was found to be equal to 50.8 ± 7.6 mM at the first day of incubation with LLC/R9 cells and decreased by 1.9 (p 0.05) and 2.1 (p 0.05) times at the 2nd and 3rd days, respectively. Despite the almost identical ІC50 at the 2nd and 3rd days, an increase in the incubation period of cells with DCA for up to 3 days increased the C0 parameter, which reflects the maximum concentration of the agent that does not exhibit cytotoxic effects, by 93% (p 0.05) compared to this at the 2nd day (16.2 ± 1.4 mM vs 8.4 ± 1.0 mM, correspondently). Unlike DCA, the LLC/R9 cell population was not homogeneous by the sensitivity to the action of MTF; at least at the 3rd day, an appearance of MTF-resistant subpopulation was observed, accounting for 35% of all cells. IC50 of MTF was equal to 12.1 ± 0.6 mM, and unlike DCA, this index progressively decreased at the 2nd and 3rd days by 1.4 (p 0.05) and 9.3 times (p 0.05) respectively. Action of DCA at a concentration of 25 mM alone and in combination with MTF at the concentrations of 0.1 mM and 0.7 mM resulted in an increase in cell migration by 65% (p 0.05), 63% (p 0.05) and 78.5% (p 0.05), respectively. There was no significant effect of MTF on the tumor cell migration. Conclusions: The sensitivity of the metastatic Lewis lung carcinoma cells to the action of the modifiers of the energy metabolism increased significantly with an increase in the incubation period, apparently, primarily due to the shortage of nutrient substrates and, in particular, glucose, indicating the relevance of their combined use as well as with other agents, which promote the deficiency of glucose in the tumor microenvironment Доп.точки доступа: Kolesnik, D. L. Pyaskovskaya, O. N. Yakshibaeva, Yu. R. Solyanik, G. I. Свободных экз. нет |
Шифр: ЕУ12/2019/41/2 Журнал 2019г. Т. 41 № 2 . - 45.41, р. Verma, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies / S. Verma [та ін.]. - С.90-94. - Bibliogr. at the end of the art. Другие авторы: Khambhala P., Joshi S., Kothari V., Patel T., Seshadri S. Syvyk, A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways / A. E. Syvyk, T. L. Syvyk. - С.95-105. - Bibliogr. at the end of the art. Prylutska, S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma / S. V. Prylutska [та ін.]. - С.106-111. - Bibliogr. at the end of the art. Другие авторы: Lynchak O. V., Kostjukov V. V., Evstigneev M. P., Remeniak O. V., Rybalchenko V. K., Prylutskyy Yu. I., Ritter U., Scharff P. Petrellis, M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma / M. C. Petrellis [та ін.]. - С.112-122. - Bibliogr. at the end of the art. Другие авторы: Frigo L., Ribeiro W., Leal-Junior E. C. P., Oliveira F. R., Maria D. A., Lopes-Martins R. Á. B. Kolesnik, D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6 / D. L. Kolesnik [та ін.]. - С.123-129. - Bibliogr. at the end of the art. Другие авторы: Pyaskovskaya O. N., Yurchenko O. V., Solyanik G. I. Herrera-Covarrubias, D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.130-137. - Bibliogr. at the end of the art. Другие авторы: Coria-Avila G. A., Aranda-Abreu G. E., Manzo J., Hernández M. E. Buchynska, L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko. - С.138-143. - Bibliogr. at the end of the art. Kravets, O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma / O. V. Kravets [та ін.]. - С.144-147. - Bibliogr. at the end of the art. Другие авторы: Protsyk V. S., Burtyn O. V., Hlynin O. V., Hurianov V. H. Burlaka, A. P. Tumor-associated redox state in metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.148-152. - Bibliogr. at the end of the art. Другие авторы: Ganusevich I. I., Burlaka A. A., Virko S. V., Kolesnik О. О. Tajaldeen, A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi / A. Tajaldeen, S. Alghamdi. - С.153-159. - Bibliogr. at the end of the art. Yakovlev, P. G. Bladder sparing surgery in high-grade bladder cancer / P. G. Yakovlev, D. A. Klyushin, R. I. Vereshchako. - С.160-165. - Bibliogr. at the end of the art. Cešeiko, R. The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment / R. Cešeiko [та ін.]. - С.166-172. - Bibliogr. at the end of the art. Другие авторы: Eglītis J., Srebnijs A., Timofejevs M., Purmalis E., Erts R., Vētra A., Tomsone S. Ben, Kridis W. Prognostic factors in metastatic gastric carcinoma / Kridis W. Ben [та ін.]. - С.173-175. - Bibliogr. at the end of the art. Другие авторы: Marrekchi G., Mzali R., Daoud J., Khanfir A. Dumanskiy, Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer / Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk. - С.176-178. - Bibliogr. at the end of the art. Starchenko, I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.]. - С.179-181. - Bibliogr. at the end of the art. Другие авторы: Dyachenko L. V., Prylutskyi O. K., Vynnyk N. I., Filenko B. M. Ben, Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity / Kridis W. Ben [та ін.]. - С.182-184. - Bibliogr. at the end of the art. Другие авторы: Werda I., Charfi S., Toumi N., Boudawara T., Mzali R., Daoud J., Khanfir A. Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Metformin enhances antitumor action of sodium dichloroacetate against glioma C6 [Текст] / D. L. Kolesnik [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 123-129. - Bibliogr. at the end of the art. Аннотация: It is known that the arsenal of chemotherapeutic agents for the treatment of malignant brain tumors is quite limited, which causes the high relevance of research aimed at finding new effective antitumor regimens, including the use of energy metabolism modifiers. Aim: To investigate the anti-glioma activity of sodium dichloroacetate (DCA) and metformin (MTF) used in combination in vitro and in vivo. Materials and Methods: Cell survival, cell cycle, apoptosis, mitochondrial membrane potential (Δψm), ATP level, the glucose consumption rate, and lactate production rate were determined in vitro in cultured glioma C6 cells. The antitumor action of agents in vivo was evaluated routinely by the prolongation of the life span of rats with transplanted intracerebral glioma C6 and was confirmed by histological examination of tumor tissue. Results: The half maximal inhibitory concentration (IC50) for DCA and MTF used separately was 79.2 ± 2.1 mM and 78.4 ± 4.0 mM, respectively, whereas IC50 for DCA used in combination with 7.8 mM MTF was 3.3 fold lower (24.0 ± 1.2 mM, p 0.05). The 1-day incubation of cells with DCA at a concentration close to IC50 (25 mM), in combination with MTF at a concentration by order lower than IC50 (7.8 mM), in contrast to their separate use, resulted in a decrease in the number of viable cells by 40% (p 0.05); redistribution of the cells by the cell cycle phases toward decreased proportion of cells in the S-phase by 46% (p 0.05) and an increased percentage of cells in the G0/G1 phase by 24% (p 0.05) compared to similar indices in the control. High proapoptotic activity of DCA in combination with MTF was supported by a significantly higher percentage of apoptotic cells in vitro than in the control (18.9 ± 4.4% vs 5.7 ± 1.3%, p 0.05) and a high number of tumor cells with signs of apoptosis revealed during the histological examination of tumor pathomorphosis. The combined effect of DCA and MTF resulted in almost 4-fold decrease of the glucose consumption rate by glioma C6 cells (0.23 ± 0.05 μmol/106 cells/h vs 0.91 ± 0.12 μmol/106 cells/h, p 0.05) compared to the corresponding parameters in the control, and 2-fold increased rate of lactate production (1.06 ± 0.03 μmol/106 cells/h vs 0.53 ± 0.03 μmol/106 cells/h, p 0.05). At the same time, both Δψm and the level of intracellular ATP in the glioma C6 cells treated with DCA and MTF, both separately and in combination, did not differ significantly from those indices in the control. In in vivo studies, the average life span of rats with intracranial transplanted glioma C6, treated with DCA in combination with MTF in a total dose of 1.1 and 2.6 g/kg body weight, respectively, was 50% higher (p 0.001) than in the control group. In contrast, in the case of single-use (at a dose of 2.6 g/kg), MTF increased the life span of tumor-bearing animals just by 19% (p 0.01), whereas DCA alone (at a dose of 1.1 g/kg) did not significantly change the survival time of rats. Conclusions: The obtained data indicate synergism of anti-glioma action of DCA and MTF in a case of their combined use both in vitro and in vivo and may be considered a starting point for the development of effective treatment regimens for malignant brain tumors based on the combined use of DCA and MTF Доп.точки доступа: Kolesnik, D. L. Pyaskovskaya, O. N. Yurchenko, O. V. Solyanik, G. I. Свободных экз. нет |