Шифр: ВУ18/2016/1 Журнал 2016г. № 1 Черних, В. П. Назустріч VIIІ Національному з’їзду фармацевтів України / В. П. Черних. - С.3 Varynskyi, B. О. Optimization of the detection conditions for the series of 1,2,4-triazole-3-thiones for FIA-ESI-MS and HPLC-ESI-MS / B. О. Varynskyi, A. G. Kaplaushenko. - С.7-11 Devyatkina, А. О. The reactivity of aromatic and heterocyclic derivatives of hydrazine. VІІ. The acid-base properties of substituted 5,7-dichloro-9-hydrazine acridine / А. О. Devyatkina [и др.]. - С.12-14 Другие авторы: Svechnikova O. M., Kolisnyk S. V., Kobzar N. P., Vinnik O. F. Anisimov, V. Yu. Development of the quantitative determination method for a new caries-preventive compound / V. Yu. Anisimov [и др.]. - С.15-18 Другие авторы: Gelmboldt V. O., Bevz N. Yu., Georgiyants V. A. Golik, M. Yu. The quantitative relationships of the partition coefficients calculated in the series of N-R-amine functional derivatives / M. Yu. Golik [и др.]. - С.19-23 Другие авторы: Kryskiv О. S., Komissarenko A. M., Kolisnyk О. V., Dudka К. І. Sych, І. V. The synthesis and physicochemical properties of new derivatives of 5-R-phenylamino-2-меrcapto-1,3,4-тhiadiazole / І. V. Sych [и др.]. - С.24-28 Другие авторы: Perekhoda L. О., Ieromina Z. G., Grinevich L. О., Kobzar N. P., Drapak І. V. Blyznyuk, N. A. A comparative phytochemical and pharmacological analysis of the extracts from leaves of the Ukrainian flora shrubs / N. A. Blyznyuk [и др.]. - С.29-32 Другие авторы: Prokopenko Yu. S., Georgiyants V. A., Tsyvunin V. V. Vovk, G. V. The amino acid and monosaccharide composition of a dry extract from Salvia officinalis leaves obtained by complex processing / G. V. Vovk, O. M. Koshovyi, A. M. Komissarenko. - С.33-35 Goy, A. M. The substantiation for introduction of the innovative technological process for industrial production of parenteral dosage forms by the example of тоrаsеміde, solution for injection / A. M. Goy. - С.36-40 Kovaliova, T. The study of properties of polymeric stabilized emulsions based on Aristoflex / T. Kovaliova, N. Polovko. - С.41-44 Tkаchuk, О. Yu. The study of the effect of the critical parameters on the manufacturing process of the oil phytoextract with the hepatoprotective action / О. Yu. Tkаchuk ; О. Yu. Тkаchuk, L. І. Vyshnevska, Т. М. Zubchenko. - С.45-49 Georgiyants, V. A. “Greening” of amizone synthesis when manufacturing / V. A. Georgiyants, V. M. Kushniruk, P. O. Bezugly. - С.50-53 Shulga, L. I. Analysis of oromucosal medicinal products in solid dosage forms for therapeutic dentistry / L. I. Shulga [и др.]. - С.54-57 Другие авторы: Chikhladze К. А., Rolik S. М., Povetkin S. О. Diadiun, T. V. Analysis of the car first aid kits of Ukraine and great Britain according to the normative documents / T. V. Diadiun, S. O. Mamedova. - С.58-61 Ovsyanikova, Yu. O. The pharmacological activity of derivatives of 4-oxo-3,4-dihydroquinazoline and anthranilamides containing a fragment of glycine / Yu. O. Ovsyanikova [и др.]. - С.62-66 Другие авторы: Levashov D. V., , Kravchenko V. M. Zamorskii, I. I. Screening of derivatives of 2-(benzoyilamino) (1-R-2-oxoindolin-3-ylidene)acetic acid under the conditions of acute hypobaric hypoxia / I. I. Zamorskii [и др.]. - С.67-70 Другие авторы: Bukataru Yu. S., Lenga E. L., Kolisnyk S. V., Altukhov O. O. Tovchiga, O. V. The effect of medicines with goutweed (Aegopodium podagraria L.) on the physical endurance, cognitive functions and the level of depression in animals / O. V. Tovchiga, S. Yu. Shtrygol’. - С.71-76 До 60-річчя завідувача кафедри органічної хімії Національного фармацевтичного університету, доктора хімічних наук, професора Шемчука Леоніда Антоновича. - С.78 Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Tovchiga, O. V. The effect of medicines with goutweed (Aegopodium podagraria L.) on the physical endurance, cognitive functions and the level of depression in animals [Text] / O. V. Tovchiga, S. Yu. Shtrygol’ // Вісн. фармації. - 2016. - № 1. - P71-76 MeSH-главная: РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология) ФИЗИЧЕСКАЯ ВЫНОСЛИВОСТЬ -- PHYSICAL ENDURANCE (действие лекарственных препаратов) ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы) Кл.слова (ненормированные): СНЫТЬ Доп.точки доступа: Shtrygol’, S. Yu. Свободных экз. нет |
Шифр: ВУ18/2017/2 Журнал 2017г. № 2 The reactivity of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids. - С.3-6 Другие авторы: Svechnikova O. M., Kolisnyk S. V., Vinnyk O. F., Kolisnyk O. V. Determination of related impurities in glimepiride tablets by the HPLC method. - С.7-12 Другие авторы: Savina N. O., Ocherethyana N. M., Britsun V. M., Ostanina N. V. Tomarovska, L. Yu. Development of the methods for atomoxetine identification suitable for the chemical and toxicological analysis / L. Yu. Tomarovska, S. V. Baiurka, S. A. Karpushyna. - С.13-20 Comparison of chromatographic methods of analysis in a thin layer of the sorbent for identification of famotidine in tablets. - С.21-24 Другие авторы: Myhal A. V., Marksa M., Golovchenko O. S., Georgiyants V. A., Ivanauskas L. The synthesis of the substituted 4-alkyl/arylsulfonyl-5-amino-3-alkylthiopyrazoles as promising pharmaceutical agents with the antifungal action. - С.25-30 Другие авторы: Tkachenko P. V., Tkachenko O. V., Netosova K. Yu., Borisov O. V., Zhuravel I. O. Slipchenko, G. D. Development of the methods for spectrophotometric determination of the flavonoid concentration in solution to study bioavailability of the amount of bioactive substances in capsules containing the powder of Scutellaria baikalensis roots and rhizomes / G. D. Slipchenko, V. O. Hrudko, O. A. Ruban. - С.31-36 The study of the chemical composition and the immunomodulatory activity of polysaccharide complexes from Veronica teucrium L. - С.37-42 Другие авторы: Osmachko A. P., Kovaleva A. M., Ilyina T. V., Kashpur N. V., Koshovyi O. M., Komisarenko A. M. Zujkina, S. S. The pharmacotechnological studies of the phytospecies composition for the complex therapy of mastopathy / S. S. Zujkina, L. I. Vishnevska. - С.43-47 Garkusha, M. I. Analysis of the Ukrainian employer current requirements to the pharmaceutical personnel / M. I. Garkusha, R. V. Sahaidak-Nikitiuk, G. A. Gretska. - С.48-53 Tovchiga, O. V. The effects of goutweed (Aegopodium podagraria L.) preparations on glycemia in intact rats and against the background of metformin / O. V. Tovchiga. - С.54-62 Tryschuk, N. M. The effect of benzilic acid derivatives on the pain threshold using the “hot plate” test / N. M. Tryschuk [та ін.]. - С.63-66 Другие авторы: Kireyev I. V., Kolisnyk S. V., Sytnik K. M. Имеются экземпляры в отделах: всего 1 Свободны: 1 |
Tovchiga, O. V. The effects of goutweed (Aegopodium podagraria L.) preparations on glycemia in intact rats and against the background of metformin [Текст] / O. V. Tovchiga // Вісн. фармації. - 2017. - № 2. - С. 54-62 MeSH-главная: РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология) ГИПОГЛИКЕМИЧЕСКИЕ СРЕДСТВА -- HYPOGLYCEMIC AGENTS (фармакология) Кл.слова (ненормированные): СНЫТЬ Аннотация: The preparations obtained from goutweed (Aegopodium podagraria L.) are characterized by favorable metabolic effects, including the antidiabetic activity. Aim. To determine the dose dependence of the effect of the extract and the tincture of goutweed on the glucose metabolism in intact rats, to evaluate the metabolic effects and the possibility of the combined use of the goutweed preparations with metformin. Materials and methods. The experiments were conducted on intact rats. The influence of the extract and the tincture of goutweed (per se and combined with metformin) on the basal glycemia and the results of the glucose tolerance test were determined. The metabolic effects which are possibly interrelated (the changes in uric acid and electrolyte exchange) were also studied. Results and discussion. The goutweed tincture exhibits the hypoglycemic action in intact rats after administration of single doses of 0.5; 1.0; 5.0 ml/kg, while the goutweed extract (100; 250; 500 mg/kg and 1.0 g/kg) does not demonstrate this action. The correlation analysis results indicate that certain interrelationship may exist between the effect of the extract on the electrolyte homeostasis and glucose metabolism (though these changes are moderate in intact animals), as well as between the effect of goutweed preparations on uric acid and the glucose exchange. The goutweed tincture in the doses of 0.5 and 1.0 ml/kg does not block the effects of metformin, and does not enhance its effect with the excessive decrease of the blood glucose concentration. The absence of a significant decrease of glycemia after combined administration of the tincture and low doses of metformin may reflect synergoantagonism (however, these phenomena were seen in intact animals, and the dose dependence of the metformin action did not change). In the glucose tolerance test the tincture in the dose of 1.0 ml/kg (but not 0.5 ml/kg) combined with metformin allows reducing its effective dose from 400 mg/kg to 200 mg/kg. Conclusions. Goutweed tincture, in contrast to the extract, shows a dose-dependent hypoglycemic effect and is promising for combined use with metformin Свободных экз. нет |
Шифр: КУ4/2016/20/4 Журнал 2016г. Т. 20 № 4 Tolochko, K. V. The basic approaches to pharmacotherapy of helminthiases and prospects of phytomedicines development for their treatment / K. V. Tolochko, L. I. Vishnevska. - С.4-10 Відмінності антитромбоцитарного лікування із застосуванням ацетилсаліцилової кислоти. - С.11-16 Другие авторы: Зупанець І. А., Запровальна О. Є., Грінцов Є. Ф., Отрішко І. А. Карбокситерапія – інноваційний метод у косметології. - С.17-23 Другие авторы: Кононенко А. В., Дроговоз С. М., Іванцик Л. Б., Асадуллаєва Н. Я., Штробля А. Л. Міщенко, О. Я. Результати частотного аналізу призначень лікарських засобів хворим на ішемічну хворобу серця як критерій оцінки якості фармакотерапії / О. Я. Міщенко, Л. В. Яковлєва, В. Ф. Осташко. - С.24-28 The study of the specific pharmacological activity of Dermabin on the model of the experimental contact dermatitis in rats. - С.30-34 Другие авторы: Karbovskyy V. L., Shevchuk I. A., Kurkina O. V., Makovska T. Ye. Narokha, V. P. The effect of the germanium complex with nicotinic acid on oxidative modification of cardiac and hepatic proteins in the experimental chronic intoxication with doxorubicin in rats / V. P. Narokha. - С.35-38 The renal effects of the goutweed (Aegopodium podagraria L.) tincture and metformin in dexamethasone-treated rats. - С.39-45 Другие авторы: Tovchiga O. V., Shtrygol S. Yu. , Taran A. V., Yudkevich T. K. Подольський, І. М. Дозозалежність ефектів перспективного антидепресанта з ноотропними властивостями 2 метил-3-(феніламінометил)-1Н-хінолін-4-ону / І. М. Подольський, С. Ю. Штриголь. - С.46-51 Ноотропні властивості тетрапептиду acetyl-(D-lys)-lys-arg-arg-amide (KK-1) на моделі хвороби Альцгеймера у щурів, зумовленої хронічним введенням скополаміну. - С.52-61 Другие авторы: Дейко Р. Д., Штриголь С. Ю., Горбач Т. В., Колобов О. О., Симбірцев А. С. Baiurka, S. V. Analytical diagnosing of milnacipran poisonings / S. V. Baiurka, S. A. Karpushyna, V. P. Moroz. - С.62-65 Имеются экземпляры в отделах: всего 1 Свободны: 1 |