Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Activation of store - operated Ca2+ entry in cisplatin resistant leukemic cells after treatment with photoexcited fullerene C60 and cisplatin / D. V. Franskevych [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P41-48

MeSH-головна:
КЛЕТОК ТРАНСФОРМАЦИЯ НЕОПЛАСТИЧЕСКАЯ -- CELL TRANSFORMATION, NEOPLASTIC
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
ЦИСПЛАТИН -- CISPLATIN
ФУЛЛЕРЕНЫ -- FULLERENES
Анотація: Ca2+-regulating system in cancer cells is suggested to be remodulated particularly by reduced store-operated Ca2+ entry (SOCE) through plasma membrane in order to maintain moderately reduced cytosolic Ca2+ concentration and to avoid apoptosis. The endoplasmic reticulum (ER) Ca2+ pool content and the size of SOCE in leukemic wild type (L1210) and resistant to cisplatin (L1210R) cells in control, after treatment with either cisplatin (1 µg/ml) or photoexcited fulleren C60 (10-5 M) alone, or their combination were estimated with the use of Indo-1 AM. The SOCE in resistant to cisplatin L1210R cells was found to be lower than in the wild-type cells. After treatment with cisplatin the decrease of thapsigargin (TG)-sensitive ER Ca2+ pool with no significant increase of SOCE was observed in L1210 cells, while no changes were detected in L1210R cells. Photoexcitation of intracellular accumulated fullerene C60 in the visible range of spectrum (410-700 nm) was accompanied by increase of SOCE not only in sensitive, but in resistant cells as well. In resistant L1210R cells treated with photoexcited C60 essential effect of cisplatin on Ca2+ homeostasis became obvious: the size of SOCE proved to be higher than after treatment with photoexcited C60 alone. The data obtained allow suggesting the influence of photoexcited C60 not only on Ca2+-regulating system, but on those involved in controlling cisplatin entry into drug resistant cancer cells
Дод.точки доступу:
Franskevych, D. V.
Grynyuk, I. I.
Prylutska, S. V.
Matyshevska, O. P.

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Adaptor protein Ruk/CIN85 induces epithelial-to-mesenchymal transition in human A549 lung adenocarcinoma cells / O. S. Vasheniuk [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P144

Дод.точки доступу:
Vasheniuk, O. S.
Gerashchenko, D. S.
Horak, I. R.
Khudiakova, O. V.
Skaterna, T. D.
Drobot, L. B.

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Adaptor protein Ruk/CIN85 is a novel molecular component of extracellular vesicles produced by tumor cells / A. Y. Zhyvolozhnyi [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P147

Дод.точки доступу:
Zhyvolozhnyi, A. Y.
Kiryakulova, M. S.
Samoylenko, A. A.
Vainio, S.
Drobot, L. B.

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Horak, I. R.
Adaptor protein Ruk/CIN85 modulates resistance to doxorubicin of murine 4T1 breast cancer cells / I. R. Horak, D. S. Gerashchenko, L. B. Drobot // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P94-100

MeSH-головна:
МОЛОЧНОЙ ЖЕЛЕЗЫ ЖИВОТНЫХ НОВООБРАЗОВАНИЯ -- MAMMARY NEOPLASMS, ANIMAL
АДАПТЕРНЫЕ БЕЛКИ ВЕЗИКУЛЯРНОГО ТРАНСПОРТА -- ADAPTOR PROTEINS, VESICULAR TRANSPORT
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
Анотація: The acquisition of chemoresistance in the course of tumor progression includes activation of membrane ABC transporters, detoxification enzymes, cell cycle deceleration and activation of specific signaling pathways such as Akt/mTOR, MAPK, NF-κB. Adaptor proteins play an essential role in the assembly of supramolecular signaling complexes, maintaining and directing the intracellular signaling. One of such proteins, called Ruk/CIN85, is strongly associated with malignant transformation and metastasis. In present study we investigated the Ruk/CIN85 effect of up/down-regulation on the transforming potential and doxorubicin resistance of highly aggressive mouse breast adenocarcinoma 4T1 cells. It was demonstrated that 4T1 cells overexpressing Ruk/CIN85 possessed increased resistance to doxorubicin (in the range of concentrations 0.1–10.0 µM) while knockdown cells were the most sensitive. Also, high levels of Ruk/CIN85 in 4T1 cells positively correlated with their ability to form colonies in semi-solid agar. Ruk/CIN85-overexpressing cells formed four times more colonies in comparison with Ruk/CIN85 nockdown cells, the growth of which revealed higher resistance to doxorubicin action
Дод.точки доступу:
Gerashchenko, D. S.
Drobot, L. B.

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Gritsenko, M.
Analysis of the expression and products accumulation of CD-marker genes in cultures of lung and skin rats fibroblasts in ontogenesis / M. Gritsenko // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P113

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Revka, O. V.
Biochemical mechanisms of fibrin clot formation and subsequent lysis regulation by platelets / O. V. Revka // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P130

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Biochemical mechanisms of free-radical damage to the nuclear genome by cadmium / I. M. Trakhtenberg [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P5-16

MeSH-головна:
КАДМИЙ -- CADMIUM (токсичность)
ХРОМАТИН -- CHROMATIN (патология)
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
Анотація: Cadmium, has been used for many years in industry and agriculture. Its active use is associated with a danger to human health due to a significant toxic effect on the body. The purpose of the review was to analyze the literature data and the results of our own experimental research on the biochemical mechanisms of the toxic effect of cadmium on the nuclear chromatin of cells, primarily the liver. Based on this analysis, the concept that the toxicity of cadmium is associated with damage caused by cadmium-induced free radicals was confirmed. The reactive oxygen species formed in this way are active damaging agents that cause toxic effects, including mutagenic, which ultimately leads to apoptosis and cell death
Дод.точки доступу:
Trakhtenberg, I. M.
Gubsky, Y. I.
Levitsky, E. L.
Belenichev, I. F.

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Spirina, V. A.
Biochemical parameters of blood with increasing concentration of nitric oxide / V. A. Spirina, O. O. Galinskij // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P137

Дод.точки доступу:
Galinskij, O. O.

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Uspenska, K. R.
Biological role of nicotinic acetylcholine receptors in mitochondria / K. R. Uspenska // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P106

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10.

Cellular plasticity as a driving force in cancer progression: the regulatory role of adaptor protein RuK/CIN85 / I. R. Horak [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P102-103

Дод.точки доступу:
Horak, I. R.
Pasichnyk, G. V.
Geraschenko, D. S.
Knopfova, L.
Borsig, L.
Drobot, L. B.

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11.

Kalmukova, O. O.
Central serotonin and tryptophan levels in rats with diet-induced obesity at the different time of melatonin administration / O. O. Kalmukova, A. V. Yurchenko, V. M. Kyryk // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P116

Дод.точки доступу:
Yurchenko, A. V.
Kyryk, V. M.

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12.

Umanska, A. O.
Changes of the performance parameters of the heart of rats for artificial hypobyosis / A. O. Umanska // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P143

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13.

Demenko, D.
Computer modeling of direct factor Xa inhibitors / D. Demenko, V. Hurmach, V. Chernyshenko // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P108

Дод.точки доступу:
Hurmach, V.
Chernyshenko, V.

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14.

Deficiency of adaptor protein RuK/CIN85 in lewis lung carcinoma cells inhibits malignancy hallmarks in vitro as well as tumor growth and pulmonary metastasis in vivo / D. S. Gerashchenko [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P111

Дод.точки доступу:
Gerashchenko, D. S.
Shytikov, D. V.
Horak, I. R.
Khudiakova, O. V.
Skaterna, T. D.
Drobot, L. B.

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15.

Development and characterization of highly informative elisa for the detection of IgG and IgA antibodies to Chlamydia trachomatis / O. Yu. Galkin [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P70-83

MeSH-головна:
ИММУНОФЕРМЕНТНЫЕ МЕТОДЫ -- IMMUNOENZYME TECHNIQUES
АНТИТЕЛА МОНОКЛОНАЛЬНЫЕ -- ANTIBODIES, MONOCLONAL
ИММУНОГЛОБУЛИН G -- IMMUNOGLOBULIN G
CHLAMYDIA TRACHOMATIS -- CHLAMYDIA TRACHOMATIS
Анотація: The goal of this work was developing of highly informative an enzyme-linked immunosorbent assay (ELISA) for the detection of IgG and IgA antibodies against to Chlamydia trachomatis, as well as comparative characterization of developed assay using standardized control materials. The study was conducted using: monoclonal antibodies (McAbs) to human IgA and IgG; recombinant Ch. trachomatis proteins – Pgp3, major outer membrane protein (MOMP); two panels of characterized sera and four reference ELISA kits. The study of immunochemical activity of peroxidase conjugates of McAbs was performed in comparison with conjugates of commercial analogues: anti-IgG McAb 2A11 and anti-IgA McAb AD3. About half of the conjugates from the received McAbs panel were more active compared to the reference antibody conjugates. It was quite justified to use the conjugates of antibodies that interact with different antigenic determinants. When IgG antibodies were detected to MOMP, it was justified 1.14-1.56 times more; when IgA antibodies were detected to MOMP, it was justified 1.16-1.37 times more. ELISA for detecting IgG/IgA antibodies to MOMP and Pgp3 of Ch. trachomatis were evaluated using appropriately described serum panels OCO-42-28-313-00 and OCO-42-28-314-00. Comparative studies of the developed ELISA for the detection of IgG and IgA antibodies to the MOMP and Pgp3 of Ch. trachomatis showed their prominent advantage over the commercial analogues, which more clearly demonstrates the difference in the ratio of average values of optical density of positive and negative samples of the described panel of sera: this indicator for commercial kits was 1.36-3.59 times less
Дод.точки доступу:
Galkin, O. Yu.
Gorshunov, Yu. Y.
Besarab, O. B.
Ivanova, O. M.

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16.

Paliienko, K. O.
Dose-dependent action of polyhexamethylene guanidine hydrochloride on release of L-[14C]glutamate from rat brain nerve terminals / K. O. Paliienko, A. O. Pastukhov // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P128

Дод.точки доступу:
Pastukhov, A. O.

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17.

Effect of glutamine deprivation on the expression of DEK, TPD52, BRCA1, ADGRE5, LIF, GNPDA1, and COL6A1 genes in IRE1 knockdown U87 glioma cells / O. Y. Luzina [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P124

Дод.точки доступу:
Luzina, O. Y.
Hnatiuk, O. S.
Garmash, Y. A.
Kharkova, A. P.

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18.

Gorshkova, O. G.
Effective method for cleaning of ore of ore-ferrous factory from ions of heavy metals based on bacteria association of the genus Pseudomonas / O. G. Gorshkova // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P112

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19.

Labudzynskyi, D. O.
Effects of cerium (IV) oxide nanoparticles on RAW 264.7 cells activity and rankl-stimulated osteoclastogenesis / D. O. Labudzynskyi, N. M. Zholobak // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P123

Дод.точки доступу:
Zholobak, N. M.

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20.

Pankiv, T. M.
Effects of intermittent fasting on respiratory capacity of mitochondria and activity of aconitase in cerebral cortex of C57BL/6 mice / T. M. Pankiv // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P129

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1-20 21-40 41-54

© Міжнародна Асоціація користувачів і розробників електронних бібліотек і нових інформаційних технологій
(Асоціація ЕБНІТ)