Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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The reactivity of ethyl esters of 2-(benzoylamino) (1-R-2-oxoindoline-3-ylidene) acetic acids [Текст] / S. V. Kolisnyk [et al.] // Вісн. фармації. - 2018. - № 2. - С. 3-7

MeSH-головна:
ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ -- HETEROCYCLIC COMPOUNDS (химический синтез)
ИНДОЛИЛУКСУСНЫЕ КИСЛОТЫ -- INDOLEACETIC ACIDS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ОРГАНИЧЕСКИЕ ВЕЩЕСТВА -- ORGANIC CHEMICALS (химический синтез)
Анотація: The studies in a series of 2-(benzoylamino)(1-R-2-oxoindoline-3-ylidene) acetic acids and their derivatives have shown that compounds of the isostructural series exhibit the nootropic, antihypoxic, anabolic activity
Дод.точки доступу:
Kolisnyk, S. V.
Svechnikova, O. M.
Vinnyk, O. F.
Kolisnyk, O. V.
Altukhov, O. O.

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Yusifova, D. Yu.
Determination of a number of indicators of “Venocoryl” ointment [Текст] / D. Yu. Yusifova, T. A. Suleymanov // Вісн. фармації. - 2018. - № 2. - С. 8-11

MeSH-головна:
МАЗИ -- OINTMENTS (анализ, стандарты)
ЛЕЩИНА -- CORYLUS (химия)
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (анализ)
ФЛАВОНОИДЫ -- FLAVONOIDS (анализ, выделение и очистка)
Анотація: o determine a number of parameters of a new medicine – 5 % “Venocoryl” ointment with the dense extract from common hazel leaves. Materials and methods. The object of our study was 7 batches of “Venocoryl” ointment developed in the laboratory conditions. In all batches such indicators as uniformity, colloidal stability, thermostability, as well as the pH of water extracts, the particle size, and the microbiological purity of the ointment were determined. The spectral characteristics of the solution were recorded; the optical density of the solution obtained was measured on a Cary 60 UV-Vis Agilent Technologies spectrophotometer (USA) in the wavelength range of 300-500 nm. Results and discussion. The ointment of all batches represents a homogeneous oily mass with light brownish-yellow color and a specific pleasant odor. All batches of the ointment meet the requirement of uniformity and satisfy the test on the colloidal stability. They are also thermostable. The pH of “Venocoryl” ointment was in the range from 5.68 to 5.75. The content of the amount of flavonoids calculated with reference to rutin should be not less than 1.0 %. Conclusions. In 7 batches of a new original medicine – “Venocoryl” ointment – a number of indicators, such as uniformity, colloidal stability, pH and thermostability has been determined; determination of the quantitative content of the amount of flavonoids has been carried out (the lower limit of the quantitative content of the amount of flavonoids calculated with reference to the substance is not less than 1.0 %). The data obtained are included in the specifications for “Venocoryl” ointment
Дод.точки доступу:
Suleymanov, T. A.

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Kovalevska, I. V.
The spectrophotometric study of thioctic acid solutions to develop the method of its quantitative determination [Текст] / I. V. Kovalevska, O. A. Ruban, V. O. Grud’ko // Вісн. фармації. - 2018. - № 2. - С. 12-18

MeSH-головна:
СПЕКТРОФОТОМЕТРИЯ -- SPECTROPHOTOMETRY (использование, методы, оборудование)
ТИОКТОВАЯ КИСЛОТА -- THIOCTIC ACID (анализ)
АНТИОКСИДАНТЫ -- ANTIOXIDANTS (анализ)
Анотація: Type II diabetes mellitus is a heterogeneous and multifactorial disease, which develops in the metabolic syndrome and significantly increases the risk of developing complications, such as angiopathy, neuropathy, retinopathy, nephropathy. Therefore, creation of new drugs that will affect all links of pathogenetic mechanism of the disease is presently topical. The main line treatment of the abovementioned pathologies is the use of antioxidant therapy. Antioxidants are important on different “lines of defense”: in the extracellular fluid, membrane and the cell cytosol. Thioctic acid belongs to these substances. The analysis of thioctic acid is of some difficulties as it has high propensity for different transformations, first of all, oxidation and polymerization. Therefore, the search of cost-neutral and at the same time rapid and effective methods of drug analysis remains relevant
Дод.точки доступу:
Ruban, O. A.
Grud’ko, V. O.

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The pharmacognostic study of the aerial part of Prangos ferulacea lindl. at the stage of the beginning of vegetation [Текст] / Yu. B. Kerimov [et al.] // Вісн. фармації. - 2018. - № 2. - С. 19-23

Рубрики: ПРАНГОС

MeSH-головна:
ЗОНТИЧНЫЕ -- APIACEAE (химия)
КУМАРИНЫ -- COUMARINS (анализ, выделение и очистка)
МАСС-СПЕКТРОМЕТРИЯ -- MASS SPECTROMETRY (использование, методы)
(ультраструктура, химия)
Анотація: To study the coumarin composition of salted Prangos ferulacea herb collected at the stage of vegetation and compare it with the coumarin composition of the freshly collected raw material. Materials and methods. The analysis was performed using Agilent 5977 GC and 7890B MS devices. The carrier gas was helium with a constant flow of 1 ml/min. The data of NIST library of standard mass-spectra were used to identify compounds. Results and discussion. The results of the study of coumarin derivatives in the food additive prepared from Prangos ferulacea herb collected at the beginning of the vegetation period are presented. The anatomical structure of the aerial part of Prangos ferulacea has been studied, and the diagnostic features of the plant raw material have been identified. Conclusions. The composition of coumarin derivatives in the food additive and in the freshly collected aerial part is identical. The diagnostic features of the structure of the plant raw material of Prangos ferulacea have been identified
Дод.точки доступу:
Kerimov, Yu. B.
Isaev, D. I.
Kerimli, E. G.
Akhmedov, E. Yu.

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Redkin, R. G.
The synthesis of spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, the study of their antimicrobial activity and the molecular docking on staphylococcal dehydrosqualene synthase [Текст] / R. G. Redkin, K. V. Hlebova // Вісн. фармації. - 2018. - № 2. - С. 24-35

MeSH-головна:
(химический синтез)
ПИРРОЛЫ -- PYRROLES (химический синтез)
МОЛЕКУЛЯРНОЙ СТЫКОВКИ МОДЕЛИРОВАНИЕ -- MOLECULAR DOCKING SIMULATION (использование, методы)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ИНДОЛЫ -- INDOLES (химический синтез)
Анотація: To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqualene synthase
Дод.точки доступу:
Hlebova, K. V.

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Sydora, N. V.
The technological aspects for complex processing of hawthorn fruits [Текст] / N. V. Sydora, A. M. Kovalyova, V. K. Iakovenko // Вісн. фармації. - 2018. - № 2. - С. 36-40

MeSH-головна:
БОЯРЫШНИК -- CRATAEGUS
(химия)
ТЕХНОЛОГИЯ -- TECHNOLOGY (методы)
Кл.слова (ненормовані):
КОМПЛЕКСНАЯ ПЕРЕРАБОТКА СЫРЬЯ
Анотація: Considering the shortage of the plant raw material the issue of its complex processing is relevant, and it contributes to its rational use. Aim. To develop the technology for complex processing of hawthorn fruits. Materials and methods. The lipophilic complex (LC) extraction was carried out with chloroform in the raw material-extractant ratio of 1 : 10; the phenolic complex (PhC) was prepared with the ethyl acetate-alcohol mixture in the ratio of 8 : 2; WSPC was obtained by triple extraction of the fruits meal after preparing LC and PhC with hot purified water followed by concentration and precipitation with 96 % ethyl alcohol. Results and discussion. It was found that the yield of LC in fruits of the hawthorn species studied was from 1 % to 10 %, the highest yield was determined in the fruits of C. submollis Sarg., C. succulenta Schrad. and C. densiflora Sarg. The yield of PhC was from 9 % to 18 %, C. submollis Sarg., C. mollis Sarg., C. arnoldiana Sarg. and C. canadensis Sarg. dominated. WSPC was from 15 % to 35 %, the highest yield was determined for fruits of C. submollis Sarg., C. macracantha Lodd, C. mollis Sarg., C. arnoldiana Sarg., C.succulenta Schrad. Conclusions. The technology of the complex processing of hawthorn fruits – C. submollis Sarg., C. mollis Sarg., C. arnoldiana Sarg., C. canadensis Sarg., C. oxyacantha L., C. monogyna Jack., C. sanguinea Pall., C. pentagyna Waldst. Et Kit., C. aronia (L.) Bosc, C. densiflora Sarg., C. succulenta Schrad, C. macracantha Lodd., C. flabellata (Bosc) C. Koch., C. pseudokyrtostylla Klok., C. ukrainica A. Pojark., C. ambiguae C. A. M – has been developed. As a result of complex processing of the plant raw material such complexes as LC, PhC and WSPC have been obtained
Дод.точки доступу:
Kovalyova, A. M.
Iakovenko, V. K.

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Kriukova, A. I.
The study of the technological and microbiological parameters of a dietary supplement “Osteovert” [Текст] / A. I. Kriukova, I. M. Vladymyrova // Вісн. фармації. - 2018. - № 2. - С. 41-47

MeSH-головна:
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL
КАПСУЛЫ -- CAPSULES
ПИЩЕВЫЕ ДОБАВКИ -- FOOD ADDITIVES
ГЛЮКОЗАМИН -- GLUCOSAMINE
ХОНДРОИТИНСУЛЬФАТЫ -- CHONDROITIN SULFATES
Анотація: The main tasks of the treatment of rheumatologic diseases include minimizing pain and inflammation in the joints, as well as restoring their functions. Duration of the treatment and the chronic course of the disease make it difficult to carry out the anti-inflammatory and analgesic therapy, which is characterized by the negative impact of non-steroidal anti-inflammatory drugs (NSAIDs) on an articular cartilage, as well as on organs of the gastrointestinal tract. In this regard, it is important to create new effective and safe products of plant origin, which use involves fewer side effects and the possibility of a longer period of use. Aim. To study the technological and microbiological parameters of the combined drug – a dietary supplement “Osteovert” in soft gelatin capsules for use in rheumatology and a dry extract of harpagophytum (Harpagophytum procumbens) used in its production
Дод.точки доступу:
Vladymyrova, I. M.

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Nemchenko, A. S.
Analysis of approaches to pharmacotherapy of patients with cardiovascular diseases according to the data of the Ukrainian and British Formularies [Текст] / A. S. Nemchenko, Yu. Ye. Kurylenko // Вісн. фармації. - 2018. - № 2. - С. 48-51

MeSH-головна:
СЕРДЕЧНО-СОСУДИСТЫЕ БОЛЕЗНИ -- CARDIOVASCULAR DISEASES (лекарственная терапия, экономика)
УКРАИНА -- UKRAINE
ВЕЛИКОБРИТАНИЯ -- GREAT BRITAIN
МЕДИЦИНСКОЙ ПОМОЩИ КАЧЕСТВО, ДОСТУПНОСТЬ И ОЦЕНКА (ВНЕШ) -- HEALTH CARE QUALITY, ACCESS, AND EVALUATION (NON MESH)
ЛЕКАРСТВ СТОИМОСТЬ ДЛЯ ПАЦИЕНТА -- FEES, PHARMACEUTICAL (стандарты)
Анотація: To analyze the approaches to pharmacotherapy of patients with cardiovascular diseases (CVD) indicated in the State Formulary of Medicines of Ukraine (SFMU) and the British National Formulary (BNF), as well as the reimbursement systems of drug cost in Ukraine and Great Britain. Materials and methods. In the course of the study materials from the on-line version of BNF No. 70 2015 and materials of SFMU No. 9 of 2017; official sites of the Ministry of Health of Ukraine and the National Health Service of Great Britain (NHS) were used. The methods of system analysis, logical generalization of information and the analytical method were also chosen
Дод.точки доступу:
Kurylenko, Yu. Ye.

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Kobets, M. M.
A social significance of the pharmacogenetic testing in Ukraine on the example of the CYP2B6 gene participating in the nicotine metabolism [Текст] / M. M. Kobets, O. V. Filiptsova, Yu. M. Kobets // Вісн. фармації. - 2018. - № 2. - С. 52-56

MeSH-головна:
ФАРМАКОГЕНЕТИКА -- PHARMACOGENETICS (методы)
НИКОТИНОВЫЕ АНТАГОНИСТЫ -- NICOTINIC ANTAGONISTS (терапевтическое применение)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC (действие лекарственных препаратов)
НИКОТИН -- NICOTINE (генетика, метаболизм)
КУРЕНИЕ -- SMOKING (генетика, лекарственная терапия, метаболизм, профилактика и контроль)
Анотація: The study of the pharmacogenetic testing in Ukraine on the example of the gene CYP2B6 participating in the nicotine metabolism is currently topical and socially significant problem. Aim. To determine the potential sample among the residents of Ukraine, for which the therapeutic effect of the treatment of nicotine addiction with bupropion will be the most effective considering polymorphism of the CYP2B6 gene. Materials and methods. Genotyping of the participants in the study with respect to CYP2B6 polymorphism (rs3745274) was carried out using a polymerase chain reaction. In addition to genotyping, the survey participants filled in questionnaires that reflected their socio-demographic data, as well as the lifestyle, duration and frequency of smoking. Results and discussion. In the course of the studies conducted it has been found that approximately 7 % of the population has a genetic variant of CYP2B6 predisposing to smoking. The same persons are a potential target audience for conducting the personalized therapy. Conclusions. Prior the pharmacotherapy it is advisable to conduct the pharmacogenetic testing, which will reduce the cost of therapy and the risk of side effects in the future
Дод.точки доступу:
Filiptsova, O. V.
Kobets, Yu. M.

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10.

The study of the antimicrobial activity of ethylene-N,N’- bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives [Текст] / Ye. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 2. - С. 57-62

MeSH-головна:
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
ИНДОЛЫ -- INDOLES (химический синтез)
ПИРРОЛЫ -- PYRROLES (химический синтез)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (использование, методы)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Анотація: To find compounds with the antimicrobial activity in the series of N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c] pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives. Materials and methods. The antimicrobial activity was studied by the agar diffusion method. Results and discussion. The antimicrobial screening data revealed the pronounced biological activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives against gramnegative (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa) and grampositive (Staphylococcus aureus, Bacillus subtilis) bacteria and as well as against Candida albicans fungi. Conclusions. The antibacterial activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives has been studied. The compounds with a significant level of the antimicrobial activity against gramnegative bacteria (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa), grampositive bacteria (Staphylococcus aureus, Bacillus subtilis), as well as against fungi (Candida albicans) have been found. According to the data of the microbiological screening the most active compounds appeared to be ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 1 and ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-5′-methyl-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 2
Дод.точки доступу:
Syumka, Ye. I.
Osolodchenko, T. P.
Chernykh, V. P.
Shemchuk, L. A.

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(Асоціація ЕБНІТ)